STEM CELL PREPARATION COMPOSITION, BATCH PRODUCTION METHOD THEREFOR AND CLINICAL USE THEREOF

A stem cell preparation composition, a batch production method therefor and a clinical use thereof. Uniformly and stably banked human embryonic stem cells are used as seeds, and formula combinations, production processes and process parameters thereof for resuspension, washing, preparation cryoprese...

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Hauptverfasser: ZHANG, Yu, LUO, Yanchao, ZHANG, Yan, WANG, Shuyan, XU, Ranran, ZHANG, Yibo, WANG, Yichao, GAN, Yidi, ZHANG, Shuai, YE, Yangmiao
Format: Patent
Sprache:chi ; eng ; fre
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Zusammenfassung:A stem cell preparation composition, a batch production method therefor and a clinical use thereof. Uniformly and stably banked human embryonic stem cells are used as seeds, and formula combinations, production processes and process parameters thereof for resuspension, washing, preparation cryopreservation, and clinical use are explored, so as to solve the problems of mass production of mesenchymal stem cell preparations and ready-to-use preparations thereof. Provided are a clinically ready-to-use mesenchymal stem cell preparation for mass production and a method for preparing same. The preparation does not contain human-derived and animal-derived auxiliary materials, and the method for preparing same comprises: performing directed differentiation and expansion on human embryonic stem cells to obtain mesenchymal stem cells, and performing processes such as resuspension, washing, preparation preparing, filling, programmed cooling, freeze preservation. Various formula combinations and various process parameters