FUNCTIONALIZED LIPOSOMAL COMPLEX, PHARMACEUTICAL COMPOSITION, COSMETIC COMPOSITION AND RELATED USES

The present invention relates to systems for the targeted delivery of active compounds to adipose tissue, more specifically to white adipocyte cells, or simply white adipocyte. The invention also relates to the functionalisation of liposomes with targeting agents for the delivery of active compounds to white adipocytes. More specifically, the present invention presents liposomes decorated with oligonucleotides, particularly aptamers, for the targeted delivery of active compounds to white adipocytes, with the aim of transforming white adipocytes into brown adipocytes. The present invention aims to provide a solution for the transformation of white adipocytes into brown adipocytes which is more efficient and causes fewer or no side effects as a result of its application via therapeutic or cosmetic compositions. La présente invention concerne des systèmes d'administration ciblée de composés actifs au tissu adipeux, plus spécifiquement aux cellules adipeuses blanches ou simplement aux adipocytes blancs. L'invention concerne également la fonctionnalisation de liposomes avec des agents de ciblage pour l'administration de composés actifs aux adipocytes blancs. Plus spécifiquement, la présente invention concerne des liposomes ornés d'oligonucléotides, plus particulièrement, des aptamères pour l'administration ciblée de composés actifs pour adipocytes blancs, visant à transformer les adipocytes blancs en adipocytes marrons. L'objectif de la présente invention est de fournir une solution pour la transformation des adipocytes blancs en adipocytes marrons, ladite solution présentant une meilleure efficacité et se soldant par la diminution ou l'absence d'effets secondaires du fait de son application par le biais de compositions thérapeutiques ou cosmétiques. A presente invenção refere-se a sistemas de entrega direcionado de compostos ativos para o tecido adiposo, mais especificamente para células adipócitas brancas, ou simplesmente adipócito branco. A invenção refere-se também à funcionalização de lipossomos com agentes de direcionamento para entrega de compostos ativos a adipócitos brancos. Mais especificamente, a presente invenção trata de lipossomos decorados com oligonucleotídeos, particularmente aptâmeros, para entrega direcionada de compostos ativos para adipócitos brancos, visando a transformação dos adipócitos brancos em adipócitos marrons. A presente invenção objetiva fornecer uma solução para transformação de adipócitos brancos em adipócitos marrons que apres