COMPOSITIONS FOR INIHIBITION OF KRAS EXPRESSION AND METHODS OF USE THEREOF

Described herein are nucleic acids and compositions thereof for inhibiting expression of the KRAS oncogene, including the KRAS mutants G12D and G12V. Also described are methods for treatment of KRAS -associated cancer, such as pancreatic cancer, using the disclosed nucleic acids. L'invention co...

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Bibliographische Detailangaben
Hauptverfasser:	MAOR ALONI, Revital, MALKA GABAI, Rachel, POLLACK-SHRAGAI, Orit, SHIRVAN, Mitchell, YARON, Michal
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Described herein are nucleic acids and compositions thereof for inhibiting expression of the KRAS oncogene, including the KRAS mutants G12D and G12V. Also described are methods for treatment of KRAS -associated cancer, such as pancreatic cancer, using the disclosed nucleic acids. L'invention concerne des acides nucléiques et des compositions de ceux-ci pour inhiber l'expression de l'oncogène KRAS, comprenant les mutants KRAS G12D et G12V. L'invention concerne également des procédés de traitement du cancer associé à KRAS, tel que le cancer du pancréas, à l'aide des acides nucléiques décrits.