METHODS FOR DETERMINING DRUG EXPOSURE IN A SUBJECT

Provided is a computer-implemented method for determining exposure of a subject to a drug, such as by determining the area under the curve. The method includes contacting a fluid of the subject, such as interstitial fluid in situ, with an electrochemical aptamer-based sensor capable of detecting the...

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Bibliographische Detailangaben
Hauptverfasser:	GONCALES, Vinicius, VAN EPS, Jeremy, BESHIRI, Agim, FRASER, Mikel, CHAMBERS, Garry
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY DIAGNOSIS ENZYMOLOGY HUMAN NECESSITIES HYGIENE IDENTIFICATION INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS SURGERY TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided is a computer-implemented method for determining exposure of a subject to a drug, such as by determining the area under the curve. The method includes contacting a fluid of the subject, such as interstitial fluid in situ, with an electrochemical aptamer-based sensor capable of detecting the drug, receiving a series of output values over a period of time, and using the series of output values or derivatives thereof to determine the exposure. L'invention concerne un procédé mis en œuvre par ordinateur pour déterminer l'exposition d'un sujet à un médicament, par exemple en déterminant la zone sous la courbe. Le procédé comprend la mise en contact d'un fluide du sujet, tel qu'un fluide interstitiel in situ, avec un capteur électrochimique à base d'aptamère capable de détecter le médicament, la réception d'une série de valeurs de sortie sur une période, et l'utilisation de la série de valeurs de sortie ou de dérivés de celles-ci pour déterminer l'exposition.