CARBONIC ANHYDRASE ENZYME INHIBITORS AND METHODS OF USE THEREOF

Provided herein are novel compounds, such as a compound of Formula I or Formula A: or a salt thereof, wherein R1-R3, L1, R10, ring A and ring B have any of the values described in the specification, as well as compositions comprising the novel compounds herein. The compounds are typically carbonic a...

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Bibliographische Detailangaben
Hauptverfasser:	SIRACUSA, Mark C, ROBERGE, Jacques Y, PIWINSKI, John, GILLERAN, John A
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided herein are novel compounds, such as a compound of Formula I or Formula A: or a salt thereof, wherein R1-R3, L1, R10, ring A and ring B have any of the values described in the specification, as well as compositions comprising the novel compounds herein. The compounds are typically carbonic anhydrase inhibitors and are useful for the prophylactic or therapeutic treatment of a disease or condition mediated by a carbonic anhydrase enzyme. L'invention concerne de nouveaux composés, tels qu'un composé de formule I ou de formule A : ou un sel de celui-ci, R1-R3, L1, R10, le cycle A et le cycle B ayant l'une quelconque des valeurs décrites dans la description, ainsi que des compositions comprenant les nouveaux composés de l'invention. Les composés sont typiquement des inhibiteurs d'anhydrase carbonique et sont utiles pour le traitement prophylactique ou thérapeutique d'une maladie ou d'un état médié par une enzyme anhydrase carbonique.