NUCLEOSIDES AND NUCLEOTIDES WITH 3´ BLOCKING GROUPS AND CLEAVABLE LINKERS

Embodiments of the present disclosure relate to nucleotide and nucleoside molecules with 3´ vinyl or isonitrile containing blocking groups and/or tetrazine or strained unsaturated ring containing cleavable linkers. Additionally, the present disclosure provides methods of using the nucleoside/nucleot...

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Bibliographische Detailangaben
Hauptverfasser:	RICHARD, Jean-Alexandre, YANG, Xiangyuan, NEELAKANDAN, Ramesh, LUKAMTO, Daniel Hartoyo
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES DERIVATIVES THEREOF ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Embodiments of the present disclosure relate to nucleotide and nucleoside molecules with 3´ vinyl or isonitrile containing blocking groups and/or tetrazine or strained unsaturated ring containing cleavable linkers. Additionally, the present disclosure provides methods of using the nucleoside/nucleotide in oligonucleotide synthesis, and methods of sequencing using the nucleotide described herein. Des modes de réalisation de la présente invention concernent des molécules nucléotidiques et nucléosidiques avec des groupes bloquants 3' contenant du vinyle ou de l'isonitrile ou des lieurs clivables contenant un cycle insaturé contraint. De plus, la présente invention concerne des procédés d'utilisation du nucléoside/nucléotide dans la synthèse d'oligonucléotides, et des procédés de séquençage utilisant le nucléotide décrit ici.