IMMUNE-ACTIVATING COMPLEXES

IMMUNE-ACTIVATING COMPLEXES

Disclosed herein are immune cells expressing engineered cytokine receptor switches which, upon activation, can direct differentiation of the immune cells. The present disclosure further provides compositions and methods for transfecting, expanding, and activating these immune cells, including substr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MCKAY, Craig Stewart, NOVINA, Carl D, REN, Jun, NEWCOMB, John R, MERMELSTEIN, Fred H, NOBILI, Alberto
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Disclosed herein are immune cells expressing engineered cytokine receptor switches which, upon activation, can direct differentiation of the immune cells. The present disclosure further provides compositions and methods for transfecting, expanding, and activating these immune cells, including substrates which activate the engineered cytokine receptor switches disclosed herein. L'invention concerne des cellules immunitaires exprimant des commutateurs de récepteur de cytokine modifiés qui, lorsqu'ils sont activés, peuvent orienter la différenciation des cellules immunitaires. La présente invention concerne en outre des compositions et des procédés de transfection, d'expansion et d'activation de ces cellules immunitaires, y compris des substrats qui activent les commutateurs de récepteur de cytokine modifiés de l'invention.