NEW CYANOPYRIDINE KHK INHIBITOR COMPOUNDS

The present invention encompasses compounds of formula (I), wherein the groups R1 to R4, have the meanings given in the claims and specification, their use as inhibitors of KHK inhibitors, pharmaceutical compositions which contain compounds of this kind and their use as medicaments, especially as ag...

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Bibliographische Detailangaben
Hauptverfasser:	KLEY, Joerg, NOSSE, Bernd, WEBER, Alexander, GOTTSCHLING, Dirk, HEINE, Niklas, PAUTSCH, Alexander
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention encompasses compounds of formula (I), wherein the groups R1 to R4, have the meanings given in the claims and specification, their use as inhibitors of KHK inhibitors, pharmaceutical compositions which contain compounds of this kind and their use as medicaments, especially as agents for treatment and/or prevention of NAFLD, NASH and type II diabetes. La présente invention concerne des composés de formule (I), dans laquelle les groupes R1 à R4 ont les significations données dans les revendications et la description, leur utilisation en tant qu'inhibiteurs de KHK, des compositions pharmaceutiques qui contiennent des composés de ce type et leur utilisation en tant que médicaments, en particulier en tant qu'agents pour le traitement et/ou la prévention de la stéatose hépatique non alcoolique (NAFLD), de la stéatohépatite non alcoolique (NASH) et du diabète de type II.