AMIDE COMPOUNDS AS ACTIVATORS OF THE POTASSIUM CHANNELS KV7.2/KV7.3 USEFUL IN THE TREATMENT OF CNS AND PNS DISORDERS

The present invention relates to compounds of formula (I) as defined in the specification capable of promoting the opening of Kv7.2/Kv7.3 potassium channels, a pharmaceutical composition comprising them, and their use as a drug, particularly in the treatment of disorders of the central nervous syste...

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Bibliographische Detailangaben
Hauptverfasser:	KNIGHT, Jamie David, OMBRATO, Rosella, PALLIN, Thomas David, PRATI, Federica, SAVY, Pascal, GAROFALO, Barbara
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to compounds of formula (I) as defined in the specification capable of promoting the opening of Kv7.2/Kv7.3 potassium channels, a pharmaceutical composition comprising them, and their use as a drug, particularly in the treatment of disorders of the central nervous system (CNS), such as, for example, epilepsy and neurodegenerative disorders, and of the peripheral nervous system (PNS), such as, for example, chronic and neuropathic pain. La présente invention concerne des composés de formule (I) tels que définis dans la description capables de favoriser l'ouverture de canaux potassiques Kv7.2/Kv7.3, une composition pharmaceutique les comprenant, et leur utilisation en tant que médicament, en particulier dans le traitement de troubles du système nerveux central (SNC), tels que, par exemple, l'épilepsie et les troubles neurodégénératifs, et du système nerveux périphérique (SNP), tels que, par exemple, la douleur chronique et neuropathique.