KRAS INHIBITORS AND PHARMACEUTICAL USES THEREOF

The disclosure relates to KRAS inhibitor compounds having the structure of Formula (I), pharmaceutical compositions thereof, and methods of use thereof for inhibiting, treating, and/or preventing KRAS-associated diseases, disorders and conditions. L'invention concerne des composés inhibiteurs d...

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Bibliographische Detailangaben
Hauptverfasser:	LU, Jiasheng, GE, Jian, WU, Gang, DU, Xianchao, ZONG, Bin, HE, Xiaolin, WANG, Linxin, SHI, Mengchao, JI, Xiang, KONG, Xianqi, ZHOU, Tianlun, YE, Xiangsheng, ZHANG, Qiguo, CHEN, Dawei, WU, Yanpeng
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The disclosure relates to KRAS inhibitor compounds having the structure of Formula (I), pharmaceutical compositions thereof, and methods of use thereof for inhibiting, treating, and/or preventing KRAS-associated diseases, disorders and conditions. L'invention concerne des composés inhibiteurs de KRAS ayant la structure de formule (I), des compositions pharmaceutiques à base de ceux-ci, et des procédés d'utilisation correspondants pour inhiber, traiter et/ou prévenir des maladies, des troubles et des états pathologiques associés à KRAS.