2-ARYLBENZIMIDAZOLE COMPOUNDS FOR THE TREATMENT OF HEMOGLOBINOPATHIES

The present disclosure provides 2-arylbenzimidazole compounds and pharmaceutical compositions or formulations thereof for the treatment of hemoglobinopathies in a subject. In some embodiments, the hemoglobinopathy is a sickle cell disease (SCD). The present disclosure also provides 2-arylbenzimidazo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	KAKKAR, Sanjay Kumar, HANNESTAD, Jonas O'Gara
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present disclosure provides 2-arylbenzimidazole compounds and pharmaceutical compositions or formulations thereof for the treatment of hemoglobinopathies in a subject. In some embodiments, the hemoglobinopathy is a sickle cell disease (SCD). The present disclosure also provides 2-arylbenzimidazole compounds and pharmaceutical compositions or formulations thereof for increasing fetal hemoglobin (HbF) production in a subject. La présente divulgation concerne des composés de 2-arylbenzimidazole et des compositions pharmaceutiques ou des formulations de ceux-ci pour le traitement d'hémoglobinopathies chez un sujet. Dans certains modes de réalisation, l'hémoglobinopathie est une drépanocytose (SCD). La présente divulgation concerne également des composés de 2-arylbenzimidazole et des compositions pharmaceutiques ou des formulations de ceux-ci pour augmenter la production d'hémoglobine fœtale (HbF) chez un sujet.