CYCLIC PYRAZOLE DIAMIDE IRE1/XBP1S ACTIVATORS

Provided herein are compounds that activate IRE1/XBP1s, and pharmaceutically acceptable derivatives thereof. Also provided are pharmaceutical compositions containing the compounds and methods of using the compounds for treating a subject having a disease or disorder that may be ameliorated by increa...

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Bibliographische Detailangaben
Hauptverfasser:	QIN, Bo, QIU, Huang, LABAUDINIERE, Richard F, PETRASSI, Hank Michael James, TAIT, Bradley Dean
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided herein are compounds that activate IRE1/XBP1s, and pharmaceutically acceptable derivatives thereof. Also provided are pharmaceutical compositions containing the compounds and methods of using the compounds for treating a subject having a disease or disorder that may be ameliorated by increasing IRE1/XBP1s activity. L'invention concerne des composés qui activent IRE1/XBP1, et des dérivés pharmaceutiquement acceptables de ceux-ci. L'invention concerne également des compositions pharmaceutiques contenant les composés et des procédés d'utilisation des composés pour traiter un sujet présentant une maladie ou un trouble qui peut être amélioré par l'augmentation de l'activité de IRE1/XBP1.