7-AZAINDOLE COMPOUNDS, PREPARATION METHOD THEREFOR, AND USE THEREOF

Disclosed in the present invention are 7-azaindole compounds, a preparation method therefor, and the use thereof, belonging to the field of drug synthesis. The present invention particularly relates to 7-azaindole compounds containing pyrazole or indole substitution represented by general formula (I), a preparation method therefor, and the use thereof in medicine. The compounds of the present invention alleviate cancer cachexia skeletal muscle atrophy by means of inhibiting ActRIIB protein in the MSTN pathway, thereby achieving a remarkable anti-cancer-cachexia effect. Experimental results show that the compounds have good anti-cachexia activity and thus can further be used for preparing novel anti-cachexia drugs. La présente invention concerne des composés de 7-azaindole, leur procédé de préparation et leur utilisation, appartenant au domaine de la synthèse de médicaments. La présente invention concerne en particulier des composés de 7-azaindole contenant une substitution pyrazole ou indole représentée par l