ANTI-TMPRSS6 ANTIBODIES AND USES THEREOF

Antibodies and antigen-binding fragments thereof that bind type II transmembrane serine protease 6 (TMPRSS6) on the surface of a cell and increase hepcidin expression, and methods for treating disorders of iron metabolism and myeloproliferative disorders using anti-TMPRSS6 antibodies and fragments,...

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Bibliographische Detailangaben
Hauptverfasser:	WANG, Yu Jean, SAVAGE, William, YANG, Hua, MILLER, Mahaney, CHEN, Buxin, YU, Jonathan, DU, Xin
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Antibodies and antigen-binding fragments thereof that bind type II transmembrane serine protease 6 (TMPRSS6) on the surface of a cell and increase hepcidin expression, and methods for treating disorders of iron metabolism and myeloproliferative disorders using anti-TMPRSS6 antibodies and fragments, are provided. L'invention concerne des anticorps et des fragments de liaison à l'antigène de ceux-ci qui se lient à la sérine protéase transmembranaire de type II 6 (TMPRSS6) sur la surface d'une cellule et augmentent l'expression de l'hepcidine, et des méthodes de traitement de troubles du métabolisme du fer et de troubles myéloprolifératifs à l'aide d'anticorps et de fragments anti-TMPRSS6.