PROCESS AND INTERMEDIATES FOR PREPARING ((1R,2S,4R)-4-((5-(4-((R)-7-CHLORO-1,2,3,4-TETRAHYDROISOQUINOLIN-1-YL)-5-METHYLTHIOPHENE-2-CARBONYL)PYRIMIDIN-4-YL)AMINO)-2-HYDROXYCYCLOPENTYL)METHYL SULFAMATE

PROCESS AND INTERMEDIATES FOR PREPARING ((1R,2S,4R)-4-((5-(4-((R)-7-CHLORO-1,2,3,4-TETRAHYDROISOQUINOLIN-1-YL)-5-METHYLTHIOPHENE-2-CARBONYL)PYRIMIDIN-4-YL)AMINO)-2-HYDROXYCYCLOPENTYL)METHYL SULFAMATE

The present disclosure relates to a process for preparing ((1R,2S,4R)-4-((5-(4-((R)-7- chloro-1,2,3,4-tetrahydroisoquinolin-1-yl)-5-methylthiophene-2-carbonyl)pyrimidin-4- yl)amino)-2-hydroxycyclopentyl)methyl sulfamate and to novel intermediates used in the process. La présente invention concerne u...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BAILEY, John Daniel, TRUONG, Jonathan Vinh-Phu, WAETZIG, Joshua David
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The present disclosure relates to a process for preparing ((1R,2S,4R)-4-((5-(4-((R)-7- chloro-1,2,3,4-tetrahydroisoquinolin-1-yl)-5-methylthiophene-2-carbonyl)pyrimidin-4- yl)amino)-2-hydroxycyclopentyl)methyl sulfamate and to novel intermediates used in the process. La présente invention concerne un procédé de préparation de sulfamate de ((1R,2S,4R)-4-((5-(4-((R)-7-chloro-1,2,3,4-tétrahydroisoquinolin-1-yl)-5-méthylthiophène-2-carbonyl) pyrimidin-4-yl) amino)-2-hydroxycyclopentyl) méthyle et de nouveaux intermédiaires utilisés dans le procédé.