PYRROLE FUSED RING DERIVATIVE AND PHARMACEUTICAL USE THEREOF
The present invention relates to a pyrrole fused ring derivative or a stereoisomer thereof, a pharmaceutical composition thereof, and the pharmaceutical use thereof; and specifically relates to a pyrrole fused ring derivative as shown in general formula (I), or a stereoisomer, a solvate, a metabolit...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | SUN, Yi YUAN, Yonghai WEI, Yonggang XU, Xuezhen JIA, Zhilong |
| description | The present invention relates to a pyrrole fused ring derivative or a stereoisomer thereof, a pharmaceutical composition thereof, and the pharmaceutical use thereof; and specifically relates to a pyrrole fused ring derivative as shown in general formula (I), or a stereoisomer, a solvate, a metabolite, a prodrug, a pharmaceutically acceptable salt or a co-crystal thereof, a pharmaceutical composition comprising same, and the use of the compound or composition of the present application in the preparation of a drug for treating cancer. The compound of the present invention has therapeutic effects on Polθ-mediated cancers or tumors, and also has a good selectivity and low side effects.
La présente invention concerne un dérivé à cycle condensé de pyrrole ou un stéréoisomère de celui-ci, une composition pharmaceutique de celui-ci, et son utilisation pharmaceutique; et en particulier un dérivé à cycle condensé de pyrrole tel que représenté dans la formule générale (I), ou un stéréoisomère, un solvate, un métabolite |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2024109688A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2024109688A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2024109688A13</originalsourceid><addsrcrecordid>eNrjZLAJiAwK8vdxVXALDXZ1UQjy9HNXcHEN8gxzDPEMc1Vw9HNRCPBwDPJ1dHYNDfF0dvRRAKpTCPFwDXL1d-NhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHh_kYGRiaGBpZmFhaOhsbEqQIAt1Iqmg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>PYRROLE FUSED RING DERIVATIVE AND PHARMACEUTICAL USE THEREOF</title><source>esp@cenet</source><creator>SUN, Yi ; YUAN, Yonghai ; WEI, Yonggang ; XU, Xuezhen ; JIA, Zhilong</creator><creatorcontrib>SUN, Yi ; YUAN, Yonghai ; WEI, Yonggang ; XU, Xuezhen ; JIA, Zhilong</creatorcontrib><description>The present invention relates to a pyrrole fused ring derivative or a stereoisomer thereof, a pharmaceutical composition thereof, and the pharmaceutical use thereof; and specifically relates to a pyrrole fused ring derivative as shown in general formula (I), or a stereoisomer, a solvate, a metabolite, a prodrug, a pharmaceutically acceptable salt or a co-crystal thereof, a pharmaceutical composition comprising same, and the use of the compound or composition of the present application in the preparation of a drug for treating cancer. The compound of the present invention has therapeutic effects on Polθ-mediated cancers or tumors, and also has a good selectivity and low side effects.
La présente invention concerne un dérivé à cycle condensé de pyrrole ou un stéréoisomère de celui-ci, une composition pharmaceutique de celui-ci, et son utilisation pharmaceutique; et en particulier un dérivé à cycle condensé de pyrrole tel que représenté dans la formule générale (I), ou un stéréoisomère, un solvate, un métabolite</description><language>chi ; eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240530&DB=EPODOC&CC=WO&NR=2024109688A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240530&DB=EPODOC&CC=WO&NR=2024109688A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SUN, Yi</creatorcontrib><creatorcontrib>YUAN, Yonghai</creatorcontrib><creatorcontrib>WEI, Yonggang</creatorcontrib><creatorcontrib>XU, Xuezhen</creatorcontrib><creatorcontrib>JIA, Zhilong</creatorcontrib><title>PYRROLE FUSED RING DERIVATIVE AND PHARMACEUTICAL USE THEREOF</title><description>The present invention relates to a pyrrole fused ring derivative or a stereoisomer thereof, a pharmaceutical composition thereof, and the pharmaceutical use thereof; and specifically relates to a pyrrole fused ring derivative as shown in general formula (I), or a stereoisomer, a solvate, a metabolite, a prodrug, a pharmaceutically acceptable salt or a co-crystal thereof, a pharmaceutical composition comprising same, and the use of the compound or composition of the present application in the preparation of a drug for treating cancer. The compound of the present invention has therapeutic effects on Polθ-mediated cancers or tumors, and also has a good selectivity and low side effects.
La présente invention concerne un dérivé à cycle condensé de pyrrole ou un stéréoisomère de celui-ci, une composition pharmaceutique de celui-ci, et son utilisation pharmaceutique; et en particulier un dérivé à cycle condensé de pyrrole tel que représenté dans la formule générale (I), ou un stéréoisomère, un solvate, un métabolite</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAJiAwK8vdxVXALDXZ1UQjy9HNXcHEN8gxzDPEMc1Vw9HNRCPBwDPJ1dHYNDfF0dvRRAKpTCPFwDXL1d-NhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHh_kYGRiaGBpZmFhaOhsbEqQIAt1Iqmg</recordid><startdate>20240530</startdate><enddate>20240530</enddate><creator>SUN, Yi</creator><creator>YUAN, Yonghai</creator><creator>WEI, Yonggang</creator><creator>XU, Xuezhen</creator><creator>JIA, Zhilong</creator><scope>EVB</scope></search><sort><creationdate>20240530</creationdate><title>PYRROLE FUSED RING DERIVATIVE AND PHARMACEUTICAL USE THEREOF</title><author>SUN, Yi ; YUAN, Yonghai ; WEI, Yonggang ; XU, Xuezhen ; JIA, Zhilong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024109688A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng ; fre</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SUN, Yi</creatorcontrib><creatorcontrib>YUAN, Yonghai</creatorcontrib><creatorcontrib>WEI, Yonggang</creatorcontrib><creatorcontrib>XU, Xuezhen</creatorcontrib><creatorcontrib>JIA, Zhilong</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SUN, Yi</au><au>YUAN, Yonghai</au><au>WEI, Yonggang</au><au>XU, Xuezhen</au><au>JIA, Zhilong</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PYRROLE FUSED RING DERIVATIVE AND PHARMACEUTICAL USE THEREOF</title><date>2024-05-30</date><risdate>2024</risdate><abstract>The present invention relates to a pyrrole fused ring derivative or a stereoisomer thereof, a pharmaceutical composition thereof, and the pharmaceutical use thereof; and specifically relates to a pyrrole fused ring derivative as shown in general formula (I), or a stereoisomer, a solvate, a metabolite, a prodrug, a pharmaceutically acceptable salt or a co-crystal thereof, a pharmaceutical composition comprising same, and the use of the compound or composition of the present application in the preparation of a drug for treating cancer. The compound of the present invention has therapeutic effects on Polθ-mediated cancers or tumors, and also has a good selectivity and low side effects.
La présente invention concerne un dérivé à cycle condensé de pyrrole ou un stéréoisomère de celui-ci, une composition pharmaceutique de celui-ci, et son utilisation pharmaceutique; et en particulier un dérivé à cycle condensé de pyrrole tel que représenté dans la formule générale (I), ou un stéréoisomère, un solvate, un métabolite</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng ; fre |
| recordid | cdi_epo_espacenet_WO2024109688A1 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PYRROLE FUSED RING DERIVATIVE AND PHARMACEUTICAL USE THEREOF |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T19%3A37%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=SUN,%20Yi&rft.date=2024-05-30&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO2024109688A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |