PYRROLE FUSED RING DERIVATIVE AND PHARMACEUTICAL USE THEREOF

The present invention relates to a pyrrole fused ring derivative or a stereoisomer thereof, a pharmaceutical composition thereof, and the pharmaceutical use thereof; and specifically relates to a pyrrole fused ring derivative as shown in general formula (I), or a stereoisomer, a solvate, a metabolit...

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Bibliographische Detailangaben
Hauptverfasser:	SUN, Yi, YUAN, Yonghai, WEI, Yonggang, XU, Xuezhen, JIA, Zhilong
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a pyrrole fused ring derivative or a stereoisomer thereof, a pharmaceutical composition thereof, and the pharmaceutical use thereof; and specifically relates to a pyrrole fused ring derivative as shown in general formula (I), or a stereoisomer, a solvate, a metabolite, a prodrug, a pharmaceutically acceptable salt or a co-crystal thereof, a pharmaceutical composition comprising same, and the use of the compound or composition of the present application in the preparation of a drug for treating cancer. The compound of the present invention has therapeutic effects on Polθ-mediated cancers or tumors, and also has a good selectivity and low side effects. La présente invention concerne un dérivé à cycle condensé de pyrrole ou un stéréoisomère de celui-ci, une composition pharmaceutique de celui-ci, et son utilisation pharmaceutique; et en particulier un dérivé à cycle condensé de pyrrole tel que représenté dans la formule générale (I), ou un stéréoisomère, un solvate, un métabolite