USE OF BENZOAZACYCLIC COMPOUND AS ALLOSTERIC MODULATOR OF β2-ADRENOCEPTOR

The present invention belongs to the field of pharmaceutical chemistry, and particularly discloses the use of a benzoazacyclic compound as an allosteric modulator of a β2-adrenoceptor. The benzoazacyclic compound of the present invention has a structure as shown in formula (I), wherein X is N or CH; Y is N or CH; R1 is any one or more of H, methyl, methoxy, phenyl, F, Cl, Br, I, CN, NO2, NH2, OH and CF3 at any position on a benzene ring; R2 is any one of H, methyl, phenyl and benzyl; R3 is any one of hydrogen and alkyl; and R4 is any one of H, alkyl, cycloalkyl, phenyl, substituted phenyl and substituted benzyl. The pharmacological results show that most synthesized benzoazacyclic compounds have a good allosteric antagonistic activity on β2-AR, and can negatively allosterically modulate the functional activity of the receptor. La présente invention appartient au domaine de la chimie pharmaceutique, et divulgue en particulier l'utilisation d'un composé benzoazacyclique en tant que modulateur allostérique d'un