MITOMYCIN C PRODRUG, AND PREPARATION METHOD THEREFOR AND USE THEREOF

A mitomycin C prodrug, and a preparation method therefor and a use thereof. The mitomycin C prodrug takes a 4-azido-2,3,5,6-tetrafluorobenzyl alcohol structure as a response group. Compared with a mitomycin C original drug, the prodrug can obtain semi-active targeting property under the guidance of...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: YUE, Siyuan, GENG, Jin
Format: Patent
Sprache:chi ; eng ; fre
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A mitomycin C prodrug, and a preparation method therefor and a use thereof. The mitomycin C prodrug takes a 4-azido-2,3,5,6-tetrafluorobenzyl alcohol structure as a response group. Compared with a mitomycin C original drug, the prodrug can obtain semi-active targeting property under the guidance of X-rays in radiotherapy and chemotherapy combined use, can relieve damage to normal cells of the whole body without sacrificing the treatment effect, and can relieve adverse reactions of patients. Compared with an antibody-drug conjugate also having the targeting property, the semi-active targeting property of the mitomycin C prodrug is from X-rays emitted by radiotherapy equipment, can be directly artificially controlled, and does not require cancer cells to have specific antigen properties, and the application range is wider. In addition, the mitomycin C prodrug is a relatively simple small molecule compound, has stable chemical properties, and has remarkable advantages compared with the antibody-drug conjugate in