SELF-REPLICATING RNA AND USES THEREOF

The technology described herein is directed to compositions and methods for modifying and controlling the activity of cells by expression of proteins from self-amplifying RNA (saRNA). Also described herein are compositions and methods for modifying and controlling the activity of cells by expression...

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Bibliographische Detailangaben
Hauptverfasser:	GRINSTAFF, Mark W, WONG, Wilson, MCGEE, Joshua Edward, KIRSCH, Jack Rainier, BRESSLER, Eric, SERTSE, Lidya Yidnekachew, LI, Kexin
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The technology described herein is directed to compositions and methods for modifying and controlling the activity of cells by expression of proteins from self-amplifying RNA (saRNA). Also described herein are compositions and methods for modifying and controlling the activity of cells by expression of proteins from self-amplifying RNA that is substituted with chemically modified nucleotides. La technologie décrite dans la présente invention concerne des compositions et des procédés pour modifier et contrôler l'activité de cellules par expression de protéines issues d'ARN auto-amplifiant (ARNaa). L'invention concerne également des compositions et des procédés pour modifier et contrôler l'activité de cellules par expression de protéines issues d'ARN auto-amplifiant qui est substitué par des nucléotides chimiquement modifiés.