FUSION PROTEINS THAT BIND AMYLOID AND THE TRANSFERRIN RECEPTOR AND USES THEREOF

FUSION PROTEINS THAT BIND AMYLOID AND THE TRANSFERRIN RECEPTOR AND USES THEREOF

The present disclosure relates in some aspects to compositions and methods of using variable domain of immunoglobulin new antigen receptor (VNAR)-Fc-peptide fusion proteins that are capable of uptake across the blood-brain barrier (BBB) and can target amyloids, including those associated with brain...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SELVARAJAH, Suganya, STOCKI, Pawel, VICK, Andrew, GAUHAR, Aziz, WALL, Jonathan S, COKER, Shu-Fen
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure relates in some aspects to compositions and methods of using variable domain of immunoglobulin new antigen receptor (VNAR)-Fc-peptide fusion proteins that are capable of uptake across the blood-brain barrier (BBB) and can target amyloids, including those associated with brain diseases, for clearance. La présente divulgation concerne, selon certains aspects, des compositions et des procédés d'utilisation de protéines de fusion de peptide Fc à domaine variable du nouveau récepteur d'antigène de l'immunoglobuline (VNAR) qui sont capables d'une absorption à travers la barrière hémato-encéphalique (BBB) et qui peuvent cibler des amyloïdes, notamment ceux associés à des maladies cérébrales, pour élimination.