MACROCYCLIC KRAS INHIBITORS AND METHODS OF USE

MACROCYCLIC KRAS INHIBITORS AND METHODS OF USE

The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S, G13D, Q61H, Q61L or G12C. The compounds have a general Formula I' (I') wherein the variables of Formula I' are defined herein. This disclosure also provides pharmaceutical compositions...

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Bibliographische Detailangaben
Hauptverfasser: LI, Yunxiao, SIEGMUND, Aaron C, NAVARATNE, Primali Vasundera, AMEGADZIE, Albert, LANMAN, Brian Alan, TERCENIO, Quentin, ZHAO, Wei, RAHIMOFF, Rene, BOOKER, Shon, WIGMAN, Benjamin, WURZ, Ryan Paul, YAMANO, Michael Masaharu, LI, Xiaofen, LI, Kexue, STELLWAGEN, John Charles, PETTUS, Liping H, EMMETIERE, Fabien, BAUER, Adriano, WU, Zhichen, MOHR, Christopher, MEDINA, Jose M, CHEN, Ning, SMALIGO, Andrew, LIU, Qingyian
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S, G13D, Q61H, Q61L or G12C. The compounds have a general Formula I' (I') wherein the variables of Formula I' are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer. La présente invention concerne des composés utiles pour l'inhibition de KRAS G12D, G12V, G12A, G12S, G13D, Q61H, Q61L ou G12C. Les composés ont une formule générale I' (I'), les variables de formule I' étant telles que définies dans la description. La présente invention concerne également des compositions pharmaceutiques comprenant les composés, des utilisations des composés, et des compositions pour le traitement, par exemple, du cancer.