GENETICALLY MODIFIED BENZYLISOQUINOLINE ALKALOID-PRODUCING HOST CELLS WITH MODIFIED EFFLUX TRANSPORTER GENE EXPRESSION

The invention relates to genetically modified hosts cell comprising a recombinant pathway having enhanced production of one or more benzylisoquinoline alkaloids or glycosylated benzylisoquinoline alkaloid, wherein the host cell has been further modified so as to have an increased ability to export e...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	HOUGHTON-LARSEN, Jens, HANSEN, Esben Halkjaer, LYNEBORG, Pernille, BAČINSKAJA, Giedrė, RECORDA, Laura Tatjer
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The invention relates to genetically modified hosts cell comprising a recombinant pathway having enhanced production of one or more benzylisoquinoline alkaloids or glycosylated benzylisoquinoline alkaloid, wherein the host cell has been further modified so as to have an increased ability to export end products of the recombinant pathway (such as nororipavine or gly-nororipavine). L'invention concerne une cellule hôte génétiquement modifiée comprenant une voie recombinante ayant une production améliorée d'un ou de plusieurs alcaloïdes de benzylisoquinoline ou d'alcaloïde de benzylisoquinoline glycosylée, la cellule hôte ayant été en outre modifiée de façon à avoir une capacité accrue à exporter des produits finaux de la voie recombinante (telle que la nororipavine ou la gly-nororipavine).