1,5-NAPHTHYRIDINE CGAS INHIBITOR AND USE THEREOF

Disclosed in the present invention are a compound having a cGAS inhibitory effect or a pharmaceutically acceptable salt thereof, and a use thereof in the preparation of a drug for diseases related to the aberrant expression of cGASs. Specifically disclosed is a compound as represented by formula (I0...

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Bibliographische Detailangaben
Hauptverfasser:	LIU, Dongzhou, YU, Xiang, CHEN, Shulun, LI, Ke, ZHAO, Mengting, ZHAI, Wenqiang
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed in the present invention are a compound having a cGAS inhibitory effect or a pharmaceutically acceptable salt thereof, and a use thereof in the preparation of a drug for diseases related to the aberrant expression of cGASs. Specifically disclosed is a compound as represented by formula (I0) and a pharmaceutically acceptable salt thereof. La présente invention concerne un composé ayant un effet inhibiteur de cGAS ou un sel pharmaceutiquement acceptable de celui-ci, et une utilisation de celui-ci dans la préparation d'un médicament pour des maladies associées à l'expression aberrante de cGAS. L'invention concerne spécifiquement un composé tel que représenté par la formule (I0) et un sel pharmaceutiquement acceptable de celui-ci. 本发明公开一类具有cGAS抑制作用的化合物或其药学上可接受的盐，及其在制备cGAS异常表达相关疾病的药物中的应用。具体公开了式(I0)所示化合物或其药学上可接受的盐。