DEUBIQUITINASE-TARGETING CHIMERAS AND RELATED METHODS
Described herein are bifunctional compounds, as well as pharmaceutically acceptable salts, hydrates, solvates, prodrugs, stereoisomers, or tautomers thereof, that function to recruit certain deubiquitinases to a target protein for modulation (e.g., stabilization) of the target protein, as well as me...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Zusammenfassung: | Described herein are bifunctional compounds, as well as pharmaceutically acceptable salts, hydrates, solvates, prodrugs, stereoisomers, or tautomers thereof, that function to recruit certain deubiquitinases to a target protein for modulation (e.g., stabilization) of the target protein, as well as methods of use thereof.
L'invention concerne des composés bifonctionnels, ainsi que des sels, des hydrates, des solvates, des promédicaments, des stéréoisomères ou des tautomères pharmaceutiquement acceptables de ceux-ci, qui fonctionnent pour recruter certaines désubiquitinases au niveau d'une protéine cible à des fins de modulation (par exemple, stabilisation) de la protéine cible, ainsi que des procédés d'utilisation de ceux-ci. |
|---|