COMPOSITION FOR PREVENTING OR TREATING MOYAMOYA DISEASE

The present invention relates to: a composition for preventing or treating Moyamoya disease, comprising, as an active ingredient, miRNAs or extracellular vesicles comprising same; and a composition for preventing or treating Moyamoya disease, comprising extracellular vesicles derived from a three-di...

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Bibliographische Detailangaben
Hauptverfasser:	KIM, Eun Hee, LEE, Na Eun, LEE, Woo Joo, OH, Gyun Sik
Format:	Patent
Sprache:	eng ; fre ; kor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to: a composition for preventing or treating Moyamoya disease, comprising, as an active ingredient, miRNAs or extracellular vesicles comprising same; and a composition for preventing or treating Moyamoya disease, comprising extracellular vesicles derived from a three-dimensional spheroid-type cell aggregate prepared by means of a novel preparation method. If miRNAs or extracellular vesicles comprising same, of the present invention, are used, the expression of miRNAs, which are downregulated in patients with Moyamoya disease or Moyamoya syndrome, is increased such that vascular anastomoses, an increase in cerebral blood vessel diameter, and an increase in cerebral blood flow can be induced. Therefore, miRNAs or extracellular vesicles comprising same, of the present invention, can be used as a novel therapeutic agent for treating Moyamoya disease or Moyamoya syndrome. La présente invention concerne : une composition pour prévenir ou traiter la maladie de Moyamoya, comprenant, en tant que principe actif, des miARN ou des vésicules extracellulaires les comprenant; et une composition pour prévenir ou traiter la maladie de Moyamoya, comprenant des vésicules extracellulaires dérivées d'un agrégat cellulaire de type sphéroïde tridimensionnel préparé au moyen d'un nouveau procédé de préparation. Si des miARN ou des vésicules extracellulaires les comprenant, de la présente invention, sont utilisés, l'expression de miARN, qui sont régulés à la baisse chez des patients atteints de la maladie de Moyamoya ou du syndrome de Moyamoya, est augmentée de telle sorte que des anastomoses vasculaires, une augmentation du diamètre de vaisseau sanguin cérébral, et une augmentation du débit sanguin cérébral peuvent être induites. Par conséquent, des miARN ou des vésicules extracellulaires les comprenant, de la présente invention, peuvent être utilisés en tant que nouvel agent thérapeutique pour le traitement de la maladie de Moyamoya ou du syndrome de Moyamoya. 본 발명은 miRNA; 또는 이를 포함하는 세포외소포를 유효성분으로 하는 모야모야 병 예방 또는 치료용 조성물 및 새로운 제조방법으로 제조된 3차원 스페로이드형 세포 응집체 유래 세포외소포를 포함하는 모야모야 병 예방 또는 치료용 조성물에 관한 것이다. 본 발명의 miRNA 또는 이를 포함하는 세포외소포를 이용하면, 모야모야 병 또는 모야모야 증훈군 환자에서 하향 조절된 miRNA 발현을 증가시킴으로써, 혈관 문합, 뇌혈관 직경 증가 및 뇌 혈류량 증가를 유도할 수 있다. 따라서 본 발명의 miRNA 또는 이를 포함하는 세포외소포는 모야모야 병 또는 모야모야 증후군을 치료하는 새로운 치료제로 활용할 수 있다.