SMALL MOLECULAR WEIGHT CHEMICAL COMPOUND TO ANTAGONIZE EPH-EPHRIN TETRAMERIZATION AND INHIBIT BIDIRECTIONAL SIGNALING
Compositions and methods for inhibiting EPH-EPHRIN tetramerization are provided. The compounds and methods herein further comprise methods for administering novel EPH-EPHRIN tetramerization inhibitors to a subject in need thereof to treat conditions caused or worsened by abnormal, defective, or exce...
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| creator | KHAMBETE, Amav AHMED, Mahmoud SPROUSE, Frances UDAMULLE GEDARA, Chinthaka Mahesh ORTIZ, Michael WANG, Hanghang HENKEMEYER, Mark SADEK, Hesham |
| description | Compositions and methods for inhibiting EPH-EPHRIN tetramerization are provided. The compounds and methods herein further comprise methods for administering novel EPH-EPHRIN tetramerization inhibitors to a subject in need thereof to treat conditions caused or worsened by abnormal, defective, or excessive EPH-EPHRIN signaling.
L'invention concerne des compositions et des procédés d'inhibition de la tétramérisation de l'EPH-EPHRINE. Les composés et les procédés de l'invention comprennent en outre des procédés d'administration de nouveaux inhibiteurs de tétramérisation d'EPH-EPHRINE à un sujet en ayant besoin pour traiter des états provoqués ou aggravés par une signalisation d'EPH-EPHRINE anormale, défectueuse ou excessive. |
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L'invention concerne des compositions et des procédés d'inhibition de la tétramérisation de l'EPH-EPHRINE. Les composés et les procédés de l'invention comprennent en outre des procédés d'administration de nouveaux inhibiteurs de tétramérisation d'EPH-EPHRINE à un sujet en ayant besoin pour traiter des états provoqués ou aggravés par une signalisation d'EPH-EPHRINE anormale, défectueuse ou excessive.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240502&DB=EPODOC&CC=WO&NR=2024092083A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240502&DB=EPODOC&CC=WO&NR=2024092083A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KHAMBETE, Amav</creatorcontrib><creatorcontrib>AHMED, Mahmoud</creatorcontrib><creatorcontrib>SPROUSE, Frances</creatorcontrib><creatorcontrib>UDAMULLE GEDARA, Chinthaka Mahesh</creatorcontrib><creatorcontrib>ORTIZ, Michael</creatorcontrib><creatorcontrib>WANG, Hanghang</creatorcontrib><creatorcontrib>HENKEMEYER, Mark</creatorcontrib><creatorcontrib>SADEK, Hesham</creatorcontrib><title>SMALL MOLECULAR WEIGHT CHEMICAL COMPOUND TO ANTAGONIZE EPH-EPHRIN TETRAMERIZATION AND INHIBIT BIDIRECTIONAL SIGNALING</title><description>Compositions and methods for inhibiting EPH-EPHRIN tetramerization are provided. The compounds and methods herein further comprise methods for administering novel EPH-EPHRIN tetramerization inhibitors to a subject in need thereof to treat conditions caused or worsened by abnormal, defective, or excessive EPH-EPHRIN signaling.
L'invention concerne des compositions et des procédés d'inhibition de la tétramérisation de l'EPH-EPHRINE. Les composés et les procédés de l'invention comprennent en outre des procédés d'administration de nouveaux inhibiteurs de tétramérisation d'EPH-EPHRINE à un sujet en ayant besoin pour traiter des états provoqués ou aggravés par une signalisation d'EPH-EPHRINE anormale, défectueuse ou excessive.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjM0KgkAURt20iOodLrQWTFvUchxvzoX5kfGK4EYkplWUYL1_E_QALT4OfBzOOnm3RmgNxmmUnRYeeqRaMUiFhqTQIJ1pXGcrYAfCsqidpQEBG5XGebLAyF4Y9DQIJmejVQFZRSUxlFSRR_n9Y6ulOoJsvU1Wt-m-hN2Pm2R_QZYqDfNzDMs8XcMjvMbe5Vl-zM55dirEofjP-gD3PDpc</recordid><startdate>20240502</startdate><enddate>20240502</enddate><creator>KHAMBETE, Amav</creator><creator>AHMED, Mahmoud</creator><creator>SPROUSE, Frances</creator><creator>UDAMULLE GEDARA, Chinthaka Mahesh</creator><creator>ORTIZ, Michael</creator><creator>WANG, Hanghang</creator><creator>HENKEMEYER, Mark</creator><creator>SADEK, Hesham</creator><scope>EVB</scope></search><sort><creationdate>20240502</creationdate><title>SMALL MOLECULAR WEIGHT CHEMICAL COMPOUND TO ANTAGONIZE EPH-EPHRIN TETRAMERIZATION AND INHIBIT BIDIRECTIONAL SIGNALING</title><author>KHAMBETE, Amav ; AHMED, Mahmoud ; SPROUSE, Frances ; UDAMULLE GEDARA, Chinthaka Mahesh ; ORTIZ, Michael ; WANG, Hanghang ; HENKEMEYER, Mark ; SADEK, Hesham</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024092083A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>KHAMBETE, Amav</creatorcontrib><creatorcontrib>AHMED, Mahmoud</creatorcontrib><creatorcontrib>SPROUSE, Frances</creatorcontrib><creatorcontrib>UDAMULLE GEDARA, Chinthaka Mahesh</creatorcontrib><creatorcontrib>ORTIZ, Michael</creatorcontrib><creatorcontrib>WANG, Hanghang</creatorcontrib><creatorcontrib>HENKEMEYER, Mark</creatorcontrib><creatorcontrib>SADEK, Hesham</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KHAMBETE, Amav</au><au>AHMED, Mahmoud</au><au>SPROUSE, Frances</au><au>UDAMULLE GEDARA, Chinthaka Mahesh</au><au>ORTIZ, Michael</au><au>WANG, Hanghang</au><au>HENKEMEYER, Mark</au><au>SADEK, Hesham</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SMALL MOLECULAR WEIGHT CHEMICAL COMPOUND TO ANTAGONIZE EPH-EPHRIN TETRAMERIZATION AND INHIBIT BIDIRECTIONAL SIGNALING</title><date>2024-05-02</date><risdate>2024</risdate><abstract>Compositions and methods for inhibiting EPH-EPHRIN tetramerization are provided. The compounds and methods herein further comprise methods for administering novel EPH-EPHRIN tetramerization inhibitors to a subject in need thereof to treat conditions caused or worsened by abnormal, defective, or excessive EPH-EPHRIN signaling.
L'invention concerne des compositions et des procédés d'inhibition de la tétramérisation de l'EPH-EPHRINE. Les composés et les procédés de l'invention comprennent en outre des procédés d'administration de nouveaux inhibiteurs de tétramérisation d'EPH-EPHRINE à un sujet en ayant besoin pour traiter des états provoqués ou aggravés par une signalisation d'EPH-EPHRINE anormale, défectueuse ou excessive.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SMALL MOLECULAR WEIGHT CHEMICAL COMPOUND TO ANTAGONIZE EPH-EPHRIN TETRAMERIZATION AND INHIBIT BIDIRECTIONAL SIGNALING |
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