SMALL MOLECULAR WEIGHT CHEMICAL COMPOUND TO ANTAGONIZE EPH-EPHRIN TETRAMERIZATION AND INHIBIT BIDIRECTIONAL SIGNALING

Compositions and methods for inhibiting EPH-EPHRIN tetramerization are provided. The compounds and methods herein further comprise methods for administering novel EPH-EPHRIN tetramerization inhibitors to a subject in need thereof to treat conditions caused or worsened by abnormal, defective, or exce...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	KHAMBETE, Amav, AHMED, Mahmoud, SPROUSE, Frances, UDAMULLE GEDARA, Chinthaka Mahesh, ORTIZ, Michael, WANG, Hanghang, HENKEMEYER, Mark, SADEK, Hesham
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Compositions and methods for inhibiting EPH-EPHRIN tetramerization are provided. The compounds and methods herein further comprise methods for administering novel EPH-EPHRIN tetramerization inhibitors to a subject in need thereof to treat conditions caused or worsened by abnormal, defective, or excessive EPH-EPHRIN signaling. L'invention concerne des compositions et des procédés d'inhibition de la tétramérisation de l'EPH-EPHRINE. Les composés et les procédés de l'invention comprennent en outre des procédés d'administration de nouveaux inhibiteurs de tétramérisation d'EPH-EPHRINE à un sujet en ayant besoin pour traiter des états provoqués ou aggravés par une signalisation d'EPH-EPHRINE anormale, défectueuse ou excessive.