PROCESS FOR MANUFACTURING ALOGABAT

The invention relates to novel processes for manufacturing 6-[[5-methyl-3-(6-methyl-3- pyridyl)isoxazol-4-yl]methoxy]-N-tetrahydropyran-4-yl-pyridazine-3-carboxamide (1), or a pharmaceutically acceptable salt thereof. The processes according to the invention are particularly suitable for large-scale...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	MODOLOLLAT, Isabelle Georgette Huguette, KOERNER, Matthias, SCALONE, Michelangelo, GUILLEMOT-PLASS, Maud, JENNY, Christian
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to novel processes for manufacturing 6-[[5-methyl-3-(6-methyl-3- pyridyl)isoxazol-4-yl]methoxy]-N-tetrahydropyran-4-yl-pyridazine-3-carboxamide (1), or a pharmaceutically acceptable salt thereof. The processes according to the invention are particularly suitable for large-scale manufacturing of the compound of formula 1 under GMP conditions. L'invention concerne de nouveaux procédés de fabrication de 6-[[5-méthyl-3-(6-méthyl-3-pyridyl) isoxazol-4-yl] méthoxy]-N-tétrahydropyran-4-yl-pyridazine-3-carboxamide (1), ou d'un sel pharmaceutiquement acceptable de celui-ci. Les procédés selon l'invention sont particulièrement adaptés à la fabrication à grande échelle du composé de formule 1 dans des conditions de BPF.