PROCESS FOR THE PREPARATION OF A GADOLINIUM CONTRAST AGENT

The present invention relates to a process for the preparation of a gadolinium chelate compound of formula (I) or its stereoisomers, tautomers, N-oxides, hydrates, solvates, or salts thereof, or mixtures of same. Further, the present invention relates to crystalline forms of the gadolinium chelate o...

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Bibliographische Detailangaben
Hauptverfasser:	GRUBE, Stefan, KUNELLIS, Jan-Christian, LONGERICH, Markus, HOG, Daniel, PLATZEK, Jonannes, ULFERTS-HÄNEL, Anita, BOEDDINGHAUS, Nicole, BALZER, Sandra, EBHARDT, Lasse, TERWILLIGER, Daniel William, JACOBS, Tia, SCHIRMER, Heiko
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to a process for the preparation of a gadolinium chelate compound of formula (I) or its stereoisomers, tautomers, N-oxides, hydrates, solvates, or salts thereof, or mixtures of same. Further, the present invention relates to crystalline forms of the gadolinium chelate of formula (I), to a process for the preparation of said crystalline forms as well as to intermediate compounds in the synthesis of the gadolinium chelate compound of formula (I) and/or its crystalline forms as well as their stereoisomers, tautomers, N-oxides, hydrates, solvates, or salts thereof, or mixtures of same. La présente invention concerne un procédé de préparation d'un composé chélate de gadolinium de formule (I) ou de ses stéréoisomères, tautomères, N-oxydes, hydrates, solvates ou sels correspondants ou des mélanges de ceux-ci. En outre, la présente invention concerne des formes cristallines du chélate de gadolinium de formule (I), un procédé de préparation desdites formes cristallines ainsi que des composés intermédiaires dans la synthèse du composé chélate de gadolinium de formule (I) et/ou ses formes cristallines ainsi que leurs stéréoisomères, tautomères, N-oxydes, hydrates, solvates ou sels correspondants ou des mélanges de ceux-ci.