TRIAZOLE-SUBSTITUTED IMIDAZO[1,2-A]PYRIMIDINES AS CGAS INHIBITORS

The present invention relates to compounds, compositions containing them, and to their use in the treatment of various disorders, in particular autoimmune, autoinflammatory or immune-mediated conditions, such as systemic lupus erythematosus (SLE), cutaneous lupus erythematosus (CLE) and lupus nephri...

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Bibliographische Detailangaben
Hauptverfasser:	REIF, Alexander, BOTYANSZKI, Janos, ZHANG, Daohua, RAMANJULU, Joshi, WIGGALL, Kenneth, CHARNLEY, Adam, KING, Bryan, NEWLANDER, Kenneth, DONG, Xiaoyang, HUMPHREYS, Philip, MARCUS, Kimberly, PERO, Joseph, RAHMAN, Attiq
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to compounds, compositions containing them, and to their use in the treatment of various disorders, in particular autoimmune, autoinflammatory or immune-mediated conditions, such as systemic lupus erythematosus (SLE), cutaneous lupus erythematosus (CLE) and lupus nephritis. La présente invention concerne des composés, des compositions les contenant, et leur utilisation dans le traitement de divers troubles, en particulier d'affections auto-immunes, auto-inflammatoires ou à médiation immunitaire, telles que le lupus érythémateux disséminé (LED), le lupus érythémateux cutané (LEC) et la néphropathie lupique.