GENE THERAPY FOR TREM2-ASSOCIATED DISEASES AND DISORDERS
Nucleic acids are described that encode for triggering receptor expressed on myeloid cells 2 (TREM2) and that can be used in expression constructs, vectors and gene therapies. Also described are methods of using the same for the treatment of TREM2-associated diseases and disorders, especially neurol...
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| creator | SHYKIND, Benjamin Michael RAUT, Priyam SEN, Anindya Kumar WILLEN, Jessica Ruth MASOUDI, Neda KAMALAKARAN, Sitharthan |
| description | Nucleic acids are described that encode for triggering receptor expressed on myeloid cells 2 (TREM2) and that can be used in expression constructs, vectors and gene therapies. Also described are methods of using the same for the treatment of TREM2-associated diseases and disorders, especially neurological diseases such as Alzheimer's Disease (AD), Adult-Onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (ALSP) or Nasu-Hakola Disease (NHD).
L'invention concerne des acides nucléiques codant pour un récepteur activateur exprimé sur des cellules myéloïdes 2 (TREM2) et qui peuvent être utilisés dans des constructions d'expression, des vecteurs et des thérapies géniques. L'invention concerne également des procédés d'utilisation de ceux-ci pour le traitement de maladies et de troubles associés à TREM2, en particulier des maladies neurologiques telles que la maladie d'Alzheimer (AD), la leucoencéphalopathie d'apparition à l'âge adulte avec des sphéroïdes axonaux et une Glia pigmentée (ALSP) ou une maladie de Nasu-Hakola (NHD). |
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L'invention concerne des acides nucléiques codant pour un récepteur activateur exprimé sur des cellules myéloïdes 2 (TREM2) et qui peuvent être utilisés dans des constructions d'expression, des vecteurs et des thérapies géniques. L'invention concerne également des procédés d'utilisation de ceux-ci pour le traitement de maladies et de troubles associés à TREM2, en particulier des maladies neurologiques telles que la maladie d'Alzheimer (AD), la leucoencéphalopathie d'apparition à l'âge adulte avec des sphéroïdes axonaux et une Glia pigmentée (ALSP) ou une maladie de Nasu-Hakola (NHD).</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | GENE THERAPY FOR TREM2-ASSOCIATED DISEASES AND DISORDERS |
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