SUBSTITUTED 1 H-PYRAZOLO-PYRIDINE AND-PYRIMIDINE COMPOUNDS
This disclosure relates to compounds of Formula (I) (I), or a pharmaceutically acceptable salt thereof, in which R3, R4, L2, W, X, Y, and Z are as 5 defined herein, to pharmaceutical compositions comprising such compounds and salts; to processes for their preparation; to intermediates used in such p...
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| creator | FREEMAN-COOK, Kevin Daniel JALAIE, Mehran JEFFREYS, Matthew Scott ZHOU, Ru DEAL, Judith Gail NAIR, Sajiv Krishnan DONALDSON, Joyann Susan KAISER, Stephen Elliott KATH, John Charles MONTGOMERY, Timothy Patrick TRAN, Khanh Tuan CHO-SCHULTZ, Sujin PATMAN, Ryan Lloyd WISNIEWSKA, Hanna Maria |
| description | This disclosure relates to compounds of Formula (I) (I), or a pharmaceutically acceptable salt thereof, in which R3, R4, L2, W, X, Y, and Z are as 5 defined herein, to pharmaceutical compositions comprising such compounds and salts; to processes for their preparation; to intermediates used in such process; and to methods of using such compounds, salts and compositions for the treatment of immunosuppression-associated disorders such as chronic viral infections and cancer. 0
La présente invention concerne des composés de formule (I) (I), ou un sel pharmaceutiquement acceptable de ceux-ci, formule dans laquelle R3, R4, L2, W, X, Y et Z sont tels que définis dans la description, des compositions pharmaceutiques comprenant de tels composés et sels ; des procédés pour leur préparation ; des intermédiaires utilisés dans un tel procédé ; et des procédés d'utilisation de tels composés, sels et compositions pour le traitement de troubles associés à l'immunosuppression tels que des infections virales chroniques et le cancer. 0 |
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La présente invention concerne des composés de formule (I) (I), ou un sel pharmaceutiquement acceptable de ceux-ci, formule dans laquelle R3, R4, L2, W, X, Y et Z sont tels que définis dans la description, des compositions pharmaceutiques comprenant de tels composés et sels ; des procédés pour leur préparation ; des intermédiaires utilisés dans un tel procédé ; et des procédés d'utilisation de tels composés, sels et compositions pour le traitement de troubles associés à l'immunosuppression tels que des infections virales chroniques et le cancer. 0</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240411&DB=EPODOC&CC=WO&NR=2024074977A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240411&DB=EPODOC&CC=WO&NR=2024074977A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FREEMAN-COOK, Kevin Daniel</creatorcontrib><creatorcontrib>JALAIE, Mehran</creatorcontrib><creatorcontrib>JEFFREYS, Matthew Scott</creatorcontrib><creatorcontrib>ZHOU, Ru</creatorcontrib><creatorcontrib>DEAL, Judith Gail</creatorcontrib><creatorcontrib>NAIR, Sajiv Krishnan</creatorcontrib><creatorcontrib>DONALDSON, Joyann Susan</creatorcontrib><creatorcontrib>KAISER, Stephen Elliott</creatorcontrib><creatorcontrib>KATH, John Charles</creatorcontrib><creatorcontrib>MONTGOMERY, Timothy Patrick</creatorcontrib><creatorcontrib>TRAN, Khanh Tuan</creatorcontrib><creatorcontrib>CHO-SCHULTZ, Sujin</creatorcontrib><creatorcontrib>PATMAN, Ryan Lloyd</creatorcontrib><creatorcontrib>WISNIEWSKA, Hanna Maria</creatorcontrib><title>SUBSTITUTED 1 H-PYRAZOLO-PYRIDINE AND-PYRIMIDINE COMPOUNDS</title><description>This disclosure relates to compounds of Formula (I) (I), or a pharmaceutically acceptable salt thereof, in which R3, R4, L2, W, X, Y, and Z are as 5 defined herein, to pharmaceutical compositions comprising such compounds and salts; to processes for their preparation; to intermediates used in such process; and to methods of using such compounds, salts and compositions for the treatment of immunosuppression-associated disorders such as chronic viral infections and cancer. 0
La présente invention concerne des composés de formule (I) (I), ou un sel pharmaceutiquement acceptable de ceux-ci, formule dans laquelle R3, R4, L2, W, X, Y et Z sont tels que définis dans la description, des compositions pharmaceutiques comprenant de tels composés et sels ; des procédés pour leur préparation ; des intermédiaires utilisés dans un tel procédé ; et des procédés d'utilisation de tels composés, sels et compositions pour le traitement de troubles associés à l'immunosuppression tels que des infections virales chroniques et le cancer. 0</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAKDnUKDvEMCQ1xdVEwVPDQDYgMcozy9_EHMTxdPP1cFRz9XMAcXwjX2d83wD_UzyWYh4E1LTGnOJUXSnMzKLu5hjh76KYW5MenFhckJqfmpZbEh_sbGRiZGJibWJqbOxoaE6cKAIvaKm4</recordid><startdate>20240411</startdate><enddate>20240411</enddate><creator>FREEMAN-COOK, Kevin Daniel</creator><creator>JALAIE, Mehran</creator><creator>JEFFREYS, Matthew Scott</creator><creator>ZHOU, Ru</creator><creator>DEAL, Judith Gail</creator><creator>NAIR, Sajiv Krishnan</creator><creator>DONALDSON, Joyann Susan</creator><creator>KAISER, Stephen Elliott</creator><creator>KATH, John Charles</creator><creator>MONTGOMERY, Timothy Patrick</creator><creator>TRAN, Khanh Tuan</creator><creator>CHO-SCHULTZ, Sujin</creator><creator>PATMAN, Ryan Lloyd</creator><creator>WISNIEWSKA, Hanna Maria</creator><scope>EVB</scope></search><sort><creationdate>20240411</creationdate><title>SUBSTITUTED 1 H-PYRAZOLO-PYRIDINE AND-PYRIMIDINE COMPOUNDS</title><author>FREEMAN-COOK, Kevin Daniel ; JALAIE, Mehran ; JEFFREYS, Matthew Scott ; ZHOU, Ru ; DEAL, Judith Gail ; NAIR, Sajiv Krishnan ; DONALDSON, Joyann Susan ; KAISER, Stephen Elliott ; KATH, John Charles ; MONTGOMERY, Timothy Patrick ; TRAN, Khanh Tuan ; CHO-SCHULTZ, Sujin ; PATMAN, Ryan Lloyd ; WISNIEWSKA, Hanna Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024074977A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>FREEMAN-COOK, Kevin Daniel</creatorcontrib><creatorcontrib>JALAIE, Mehran</creatorcontrib><creatorcontrib>JEFFREYS, Matthew Scott</creatorcontrib><creatorcontrib>ZHOU, Ru</creatorcontrib><creatorcontrib>DEAL, Judith Gail</creatorcontrib><creatorcontrib>NAIR, Sajiv Krishnan</creatorcontrib><creatorcontrib>DONALDSON, Joyann Susan</creatorcontrib><creatorcontrib>KAISER, Stephen Elliott</creatorcontrib><creatorcontrib>KATH, John Charles</creatorcontrib><creatorcontrib>MONTGOMERY, Timothy Patrick</creatorcontrib><creatorcontrib>TRAN, Khanh Tuan</creatorcontrib><creatorcontrib>CHO-SCHULTZ, Sujin</creatorcontrib><creatorcontrib>PATMAN, Ryan Lloyd</creatorcontrib><creatorcontrib>WISNIEWSKA, Hanna Maria</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>FREEMAN-COOK, Kevin Daniel</au><au>JALAIE, Mehran</au><au>JEFFREYS, Matthew Scott</au><au>ZHOU, Ru</au><au>DEAL, Judith Gail</au><au>NAIR, Sajiv Krishnan</au><au>DONALDSON, Joyann Susan</au><au>KAISER, Stephen Elliott</au><au>KATH, John Charles</au><au>MONTGOMERY, Timothy Patrick</au><au>TRAN, Khanh Tuan</au><au>CHO-SCHULTZ, Sujin</au><au>PATMAN, Ryan Lloyd</au><au>WISNIEWSKA, Hanna Maria</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SUBSTITUTED 1 H-PYRAZOLO-PYRIDINE AND-PYRIMIDINE COMPOUNDS</title><date>2024-04-11</date><risdate>2024</risdate><abstract>This disclosure relates to compounds of Formula (I) (I), or a pharmaceutically acceptable salt thereof, in which R3, R4, L2, W, X, Y, and Z are as 5 defined herein, to pharmaceutical compositions comprising such compounds and salts; to processes for their preparation; to intermediates used in such process; and to methods of using such compounds, salts and compositions for the treatment of immunosuppression-associated disorders such as chronic viral infections and cancer. 0
La présente invention concerne des composés de formule (I) (I), ou un sel pharmaceutiquement acceptable de ceux-ci, formule dans laquelle R3, R4, L2, W, X, Y et Z sont tels que définis dans la description, des compositions pharmaceutiques comprenant de tels composés et sels ; des procédés pour leur préparation ; des intermédiaires utilisés dans un tel procédé ; et des procédés d'utilisation de tels composés, sels et compositions pour le traitement de troubles associés à l'immunosuppression tels que des infections virales chroniques et le cancer. 0</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SUBSTITUTED 1 H-PYRAZOLO-PYRIDINE AND-PYRIMIDINE COMPOUNDS |
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