SUBSTITUTED 1 H-PYRAZOLO-PYRIDINE AND-PYRIMIDINE COMPOUNDS

SUBSTITUTED 1 H-PYRAZOLO-PYRIDINE AND-PYRIMIDINE COMPOUNDS

This disclosure relates to compounds of Formula (I) (I), or a pharmaceutically acceptable salt thereof, in which R3, R4, L2, W, X, Y, and Z are as 5 defined herein, to pharmaceutical compositions comprising such compounds and salts; to processes for their preparation; to intermediates used in such p...

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Bibliographische Detailangaben
Hauptverfasser: FREEMAN-COOK, Kevin Daniel, JALAIE, Mehran, JEFFREYS, Matthew Scott, ZHOU, Ru, DEAL, Judith Gail, NAIR, Sajiv Krishnan, DONALDSON, Joyann Susan, KAISER, Stephen Elliott, KATH, John Charles, MONTGOMERY, Timothy Patrick, TRAN, Khanh Tuan, CHO-SCHULTZ, Sujin, PATMAN, Ryan Lloyd, WISNIEWSKA, Hanna Maria
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:This disclosure relates to compounds of Formula (I) (I), or a pharmaceutically acceptable salt thereof, in which R3, R4, L2, W, X, Y, and Z are as 5 defined herein, to pharmaceutical compositions comprising such compounds and salts; to processes for their preparation; to intermediates used in such process; and to methods of using such compounds, salts and compositions for the treatment of immunosuppression-associated disorders such as chronic viral infections and cancer. 0 La présente invention concerne des composés de formule (I) (I), ou un sel pharmaceutiquement acceptable de ceux-ci, formule dans laquelle R3, R4, L2, W, X, Y et Z sont tels que définis dans la description, des compositions pharmaceutiques comprenant de tels composés et sels ; des procédés pour leur préparation ; des intermédiaires utilisés dans un tel procédé ; et des procédés d'utilisation de tels composés, sels et compositions pour le traitement de troubles associés à l'immunosuppression tels que des infections virales chroniques et le cancer. 0