LACTATE ENHANCING COMPOUNDS AND USES THEREOF

The present invention relates to new agents useful for stimulating uptake of glucose and release of lactate by astrocytes. The invention further relates to methods of preparation, formulations and therapeutic uses of those agents, notably for the prevention and/or treatment of neurological disorders...

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Bibliographische Detailangaben
Hauptverfasser:	FINSTERWALD, Charles, RITCHIE, Timothy, LENGACHER, Sylvain, DUVEY, Guillaume, MAAG, Hans, MAGISTRETTI, Pierre
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to new agents useful for stimulating uptake of glucose and release of lactate by astrocytes. The invention further relates to methods of preparation, formulations and therapeutic uses of those agents, notably for the prevention and/or treatment of neurological disorders with brain energy hypometabolism, in particular neurodegenerative, neurometabolic and psychiatric disorders or improving cognitive and memory functions. La présente invention concerne de nouveaux agents utiles pour stimuler l'absorption du glucose et la libération de lactate par les astrocytes. L'invention concerne en outre des procédés de préparation, des formulations et des utilisations thérapeutiques de ces agents, notamment pour la prévention et/ou le traitement de troubles neurologiques avec hypométabolisme de l'énergie cérébrale, en particulier des troubles neurodégénératifs, neurométaboliques et psychiatriques, ou l'amélioration des fonctions cognitives et de mémoire.