PYRIDAZIN-3(2H)-ONE AND PYRIDIN-2(1H)-ONE PARP INHIBITOR COMPOUNDS
The present disclosure relates to pyridazin-3(2H)-one and pyridin-2(1H)-one core compounds, related compounds, and their use in treating a disease or condition responsive to inhibition of at least one PARP protein. The compounds and methods may be used in treating a disease or condition responsive t...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | ZHOU, Yuchen WINTER, Dana K COHEN, Michael S PELLETIER, Guillaume SPELLMEYER, David C NG, Raymond A LAPOINTE, David JOHNSON, Michael G |
| description | The present disclosure relates to pyridazin-3(2H)-one and pyridin-2(1H)-one core compounds, related compounds, and their use in treating a disease or condition responsive to inhibition of at least one PARP protein. The compounds and methods may be used in treating a disease or condition responsive to inhibition of PARP7 and optionally one or more additional PARP proteins.
La présente divulgation concerne des composés à noyaux de pyridazin-3(2H)-one et de pyridin-2(1H)-one, des composés apparentés, et leur utilisation dans le traitement d'une maladie ou d'un état sensible à l'inhibition d'au moins une protéine PARP. Les composés et les procédés peuvent être utilisés dans le traitement d'une maladie ou d'un état sensible à l'inhibition de PARP7 et éventuellement une ou plusieurs protéines PARP supplémentaires. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2024073133A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2024073133A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2024073133A13</originalsourceid><addsrcrecordid>eNrjZHAKiAzydHGM8vTTNdYw8tDU9fdzVXD0c1EAiwNFjTQMoaIBjkEBCp5-Hp5OniH-QQrO_r4B_qF-LsE8DKxpiTnFqbxQmptB2c01xNlDN7UgPz61uCAxOTUvtSQ-3N_IwMjEwNzY0NjY0dCYOFUASLYrXA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>PYRIDAZIN-3(2H)-ONE AND PYRIDIN-2(1H)-ONE PARP INHIBITOR COMPOUNDS</title><source>esp@cenet</source><creator>ZHOU, Yuchen ; WINTER, Dana K ; COHEN, Michael S ; PELLETIER, Guillaume ; SPELLMEYER, David C ; NG, Raymond A ; LAPOINTE, David ; JOHNSON, Michael G</creator><creatorcontrib>ZHOU, Yuchen ; WINTER, Dana K ; COHEN, Michael S ; PELLETIER, Guillaume ; SPELLMEYER, David C ; NG, Raymond A ; LAPOINTE, David ; JOHNSON, Michael G</creatorcontrib><description>The present disclosure relates to pyridazin-3(2H)-one and pyridin-2(1H)-one core compounds, related compounds, and their use in treating a disease or condition responsive to inhibition of at least one PARP protein. The compounds and methods may be used in treating a disease or condition responsive to inhibition of PARP7 and optionally one or more additional PARP proteins.
La présente divulgation concerne des composés à noyaux de pyridazin-3(2H)-one et de pyridin-2(1H)-one, des composés apparentés, et leur utilisation dans le traitement d'une maladie ou d'un état sensible à l'inhibition d'au moins une protéine PARP. Les composés et les procédés peuvent être utilisés dans le traitement d'une maladie ou d'un état sensible à l'inhibition de PARP7 et éventuellement une ou plusieurs protéines PARP supplémentaires.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240404&DB=EPODOC&CC=WO&NR=2024073133A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,782,887,25573,76557</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240404&DB=EPODOC&CC=WO&NR=2024073133A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZHOU, Yuchen</creatorcontrib><creatorcontrib>WINTER, Dana K</creatorcontrib><creatorcontrib>COHEN, Michael S</creatorcontrib><creatorcontrib>PELLETIER, Guillaume</creatorcontrib><creatorcontrib>SPELLMEYER, David C</creatorcontrib><creatorcontrib>NG, Raymond A</creatorcontrib><creatorcontrib>LAPOINTE, David</creatorcontrib><creatorcontrib>JOHNSON, Michael G</creatorcontrib><title>PYRIDAZIN-3(2H)-ONE AND PYRIDIN-2(1H)-ONE PARP INHIBITOR COMPOUNDS</title><description>The present disclosure relates to pyridazin-3(2H)-one and pyridin-2(1H)-one core compounds, related compounds, and their use in treating a disease or condition responsive to inhibition of at least one PARP protein. The compounds and methods may be used in treating a disease or condition responsive to inhibition of PARP7 and optionally one or more additional PARP proteins.
La présente divulgation concerne des composés à noyaux de pyridazin-3(2H)-one et de pyridin-2(1H)-one, des composés apparentés, et leur utilisation dans le traitement d'une maladie ou d'un état sensible à l'inhibition d'au moins une protéine PARP. Les composés et les procédés peuvent être utilisés dans le traitement d'une maladie ou d'un état sensible à l'inhibition de PARP7 et éventuellement une ou plusieurs protéines PARP supplémentaires.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHAKiAzydHGM8vTTNdYw8tDU9fdzVXD0c1EAiwNFjTQMoaIBjkEBCp5-Hp5OniH-QQrO_r4B_qF-LsE8DKxpiTnFqbxQmptB2c01xNlDN7UgPz61uCAxOTUvtSQ-3N_IwMjEwNzY0NjY0dCYOFUASLYrXA</recordid><startdate>20240404</startdate><enddate>20240404</enddate><creator>ZHOU, Yuchen</creator><creator>WINTER, Dana K</creator><creator>COHEN, Michael S</creator><creator>PELLETIER, Guillaume</creator><creator>SPELLMEYER, David C</creator><creator>NG, Raymond A</creator><creator>LAPOINTE, David</creator><creator>JOHNSON, Michael G</creator><scope>EVB</scope></search><sort><creationdate>20240404</creationdate><title>PYRIDAZIN-3(2H)-ONE AND PYRIDIN-2(1H)-ONE PARP INHIBITOR COMPOUNDS</title><author>ZHOU, Yuchen ; WINTER, Dana K ; COHEN, Michael S ; PELLETIER, Guillaume ; SPELLMEYER, David C ; NG, Raymond A ; LAPOINTE, David ; JOHNSON, Michael G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024073133A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ZHOU, Yuchen</creatorcontrib><creatorcontrib>WINTER, Dana K</creatorcontrib><creatorcontrib>COHEN, Michael S</creatorcontrib><creatorcontrib>PELLETIER, Guillaume</creatorcontrib><creatorcontrib>SPELLMEYER, David C</creatorcontrib><creatorcontrib>NG, Raymond A</creatorcontrib><creatorcontrib>LAPOINTE, David</creatorcontrib><creatorcontrib>JOHNSON, Michael G</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZHOU, Yuchen</au><au>WINTER, Dana K</au><au>COHEN, Michael S</au><au>PELLETIER, Guillaume</au><au>SPELLMEYER, David C</au><au>NG, Raymond A</au><au>LAPOINTE, David</au><au>JOHNSON, Michael G</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PYRIDAZIN-3(2H)-ONE AND PYRIDIN-2(1H)-ONE PARP INHIBITOR COMPOUNDS</title><date>2024-04-04</date><risdate>2024</risdate><abstract>The present disclosure relates to pyridazin-3(2H)-one and pyridin-2(1H)-one core compounds, related compounds, and their use in treating a disease or condition responsive to inhibition of at least one PARP protein. The compounds and methods may be used in treating a disease or condition responsive to inhibition of PARP7 and optionally one or more additional PARP proteins.
La présente divulgation concerne des composés à noyaux de pyridazin-3(2H)-one et de pyridin-2(1H)-one, des composés apparentés, et leur utilisation dans le traitement d'une maladie ou d'un état sensible à l'inhibition d'au moins une protéine PARP. Les composés et les procédés peuvent être utilisés dans le traitement d'une maladie ou d'un état sensible à l'inhibition de PARP7 et éventuellement une ou plusieurs protéines PARP supplémentaires.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_WO2024073133A1 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PYRIDAZIN-3(2H)-ONE AND PYRIDIN-2(1H)-ONE PARP INHIBITOR COMPOUNDS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-03T07%3A55%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=ZHOU,%20Yuchen&rft.date=2024-04-04&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO2024073133A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |