PYRIDAZIN-3(2H)-ONE AND PYRIDIN-2(1H)-ONE PARP INHIBITOR COMPOUNDS

PYRIDAZIN-3(2H)-ONE AND PYRIDIN-2(1H)-ONE PARP INHIBITOR COMPOUNDS

The present disclosure relates to pyridazin-3(2H)-one and pyridin-2(1H)-one core compounds, related compounds, and their use in treating a disease or condition responsive to inhibition of at least one PARP protein. The compounds and methods may be used in treating a disease or condition responsive t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ZHOU, Yuchen, WINTER, Dana K, COHEN, Michael S, PELLETIER, Guillaume, SPELLMEYER, David C, NG, Raymond A, LAPOINTE, David, JOHNSON, Michael G
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure relates to pyridazin-3(2H)-one and pyridin-2(1H)-one core compounds, related compounds, and their use in treating a disease or condition responsive to inhibition of at least one PARP protein. The compounds and methods may be used in treating a disease or condition responsive to inhibition of PARP7 and optionally one or more additional PARP proteins. La présente divulgation concerne des composés à noyaux de pyridazin-3(2H)-one et de pyridin-2(1H)-one, des composés apparentés, et leur utilisation dans le traitement d'une maladie ou d'un état sensible à l'inhibition d'au moins une protéine PARP. Les composés et les procédés peuvent être utilisés dans le traitement d'une maladie ou d'un état sensible à l'inhibition de PARP7 et éventuellement une ou plusieurs protéines PARP supplémentaires.