IL1RAP ANTIBODIES AND USES THEREOF

The present disclosure provides isolated anti-IL1RAP antibodies comprising the complementarity determining regions (CDRs) amino acid sequences, as disclosed herein. The disclosure further provides specific variable heavy chain and variable light chain amino acid sequences of these isolated anti-IL1R...

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Bibliographische Detailangaben
Hauptverfasser:	DOYLE, Patrick James, CHEN, Jiahao, NAKAYAMA, Yasumi, BUGAJ-GAWEDA, Bozena, BENARD, Lumie Marie Josephine, GUERNAH, Ilhem, ROOPNARIANE, Adriana Permaul, KAROULIA, Zoi, CARPENITO, Carmine, BIDERMAN, Lynn, LIPPINCOTT, John Andrew, DUEY, Dana Yen Mei, LORENZ, Ivo C
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present disclosure provides isolated anti-IL1RAP antibodies comprising the complementarity determining regions (CDRs) amino acid sequences, as disclosed herein. The disclosure further provides specific variable heavy chain and variable light chain amino acid sequences of these isolated anti-IL1RAP antibodies. The anti-IL1RAP antibodies target downstream IL1RAP activity appear useful for treating diseases such as cancer. La présente divulgation concerne des anticorps anti-IL1RAP isolés comprenant des séquences d'acides aminés des régions déterminant la complémentarité (CDR). La divulgation concerne en outre des séquences d'acides aminés à chaîne lourde variable et variable spécifiques de ces anticorps anti-IL1RAP isolés. L'activité d'IL1RAP en aval d'anticorps anti-IL1RAP cibles semblent être utiles pour le traitement de maladies telles que le cancer.