A PROCESS FOR THE MANUFACTURE OF SALTS AND CRYSTALLINE FORMS OF 1-(8-BROMOPYRIDO[2,3-E][1,2,4]TRIAZOLO[4,3-A]PYRAZIN-4-YL)-N-METHYLAZETIDIN-3-AMINE AND NOVEL CRYSTALLINE FORMS
A novel process for preparation of crystalline forms and novel crystalline forms of 1-(8- bromopyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-4-yl)-N-methylazetidin-3-amine salts is provided along with pharmaceutical compositions comprising the same. Also disclosed is the use of the novel polymorph for...
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| creator | TROENSEGAARD NIELSEN, Kim HOFMANN LARSEN, Flemming KLARSKOV PETERSEN, Anders |
| description | A novel process for preparation of crystalline forms and novel crystalline forms of 1-(8- bromopyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-4-yl)-N-methylazetidin-3-amine salts is provided along with pharmaceutical compositions comprising the same. Also disclosed is the use of the novel polymorph for the treatment of diseases, such as atopic dermatitis (AD), itch, pruritus and various forms of urticaria for example chronic idiopathic urticaria subtypes.
L'invention concerne un nouveau procédé de préparation de formes cristallines et de nouvelles formes cristallines de sels de 1-(8-bromopyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-4-yl)-N-méthylazétidin-3-amine ainsi que des compositions pharmaceutiques les comprenant. L'invention concerne également l'utilisation du nouveau polymorphe pour le traitement de maladies, telles que la dermatite atopique (AD), les démangeaisons, le prurit et diverses formes d'urticaire, par exemple des sous-types d'urticaire idiopathique chronique. |
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L'invention concerne un nouveau procédé de préparation de formes cristallines et de nouvelles formes cristallines de sels de 1-(8-bromopyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-4-yl)-N-méthylazétidin-3-amine ainsi que des compositions pharmaceutiques les comprenant. L'invention concerne également l'utilisation du nouveau polymorphe pour le traitement de maladies, telles que la dermatite atopique (AD), les démangeaisons, le prurit et diverses formes d'urticaire, par exemple des sous-types d'urticaire idiopathique chronique.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240404&DB=EPODOC&CC=WO&NR=2024068851A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25547,76298</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240404&DB=EPODOC&CC=WO&NR=2024068851A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TROENSEGAARD NIELSEN, Kim</creatorcontrib><creatorcontrib>HOFMANN LARSEN, Flemming</creatorcontrib><creatorcontrib>KLARSKOV PETERSEN, Anders</creatorcontrib><title>A PROCESS FOR THE MANUFACTURE OF SALTS AND CRYSTALLINE FORMS OF 1-(8-BROMOPYRIDO[2,3-E][1,2,4]TRIAZOLO[4,3-A]PYRAZIN-4-YL)-N-METHYLAZETIDIN-3-AMINE AND NOVEL CRYSTALLINE FORMS</title><description>A novel process for preparation of crystalline forms and novel crystalline forms of 1-(8- bromopyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-4-yl)-N-methylazetidin-3-amine salts is provided along with pharmaceutical compositions comprising the same. Also disclosed is the use of the novel polymorph for the treatment of diseases, such as atopic dermatitis (AD), itch, pruritus and various forms of urticaria for example chronic idiopathic urticaria subtypes.
L'invention concerne un nouveau procédé de préparation de formes cristallines et de nouvelles formes cristallines de sels de 1-(8-bromopyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-4-yl)-N-méthylazétidin-3-amine ainsi que des compositions pharmaceutiques les comprenant. L'invention concerne également l'utilisation du nouveau polymorphe pour le traitement de maladies, telles que la dermatite atopique (AD), les démangeaisons, le prurit et diverses formes d'urticaire, par exemple des sous-types d'urticaire idiopathique chronique.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjbEKwjAURbs4iPoPAReFBmyt0vXZvtJAkidJVNpSRCROooL-l79oC24uThfOPdw7DN7AtoYytJYVZJgrkSnQuwIytzPIqGAWpLMMdM4yU1kHUgqNvaxsX0d8lvKNIUXbyoicmjhccmybKIzDpHVGQE2SmqSj0HYK1ELzhFdyzjVX6MpKQo1O5B3uFNWP92ea9ih_L8fB4HK6Pv3km6NgWqDLSu4f96N_Pk5nf_Ov44HiRZws1mm6iiBa_md9AEnWSXE</recordid><startdate>20240404</startdate><enddate>20240404</enddate><creator>TROENSEGAARD NIELSEN, Kim</creator><creator>HOFMANN LARSEN, Flemming</creator><creator>KLARSKOV PETERSEN, Anders</creator><scope>EVB</scope></search><sort><creationdate>20240404</creationdate><title>A PROCESS FOR THE MANUFACTURE OF SALTS AND CRYSTALLINE FORMS OF 1-(8-BROMOPYRIDO[2,3-E][1,2,4]TRIAZOLO[4,3-A]PYRAZIN-4-YL)-N-METHYLAZETIDIN-3-AMINE AND NOVEL CRYSTALLINE FORMS</title><author>TROENSEGAARD NIELSEN, Kim ; HOFMANN LARSEN, Flemming ; KLARSKOV PETERSEN, Anders</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024068851A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>TROENSEGAARD NIELSEN, Kim</creatorcontrib><creatorcontrib>HOFMANN LARSEN, Flemming</creatorcontrib><creatorcontrib>KLARSKOV PETERSEN, Anders</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TROENSEGAARD NIELSEN, Kim</au><au>HOFMANN LARSEN, Flemming</au><au>KLARSKOV PETERSEN, Anders</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>A PROCESS FOR THE MANUFACTURE OF SALTS AND CRYSTALLINE FORMS OF 1-(8-BROMOPYRIDO[2,3-E][1,2,4]TRIAZOLO[4,3-A]PYRAZIN-4-YL)-N-METHYLAZETIDIN-3-AMINE AND NOVEL CRYSTALLINE FORMS</title><date>2024-04-04</date><risdate>2024</risdate><abstract>A novel process for preparation of crystalline forms and novel crystalline forms of 1-(8- bromopyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-4-yl)-N-methylazetidin-3-amine salts is provided along with pharmaceutical compositions comprising the same. Also disclosed is the use of the novel polymorph for the treatment of diseases, such as atopic dermatitis (AD), itch, pruritus and various forms of urticaria for example chronic idiopathic urticaria subtypes.
L'invention concerne un nouveau procédé de préparation de formes cristallines et de nouvelles formes cristallines de sels de 1-(8-bromopyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-4-yl)-N-méthylazétidin-3-amine ainsi que des compositions pharmaceutiques les comprenant. L'invention concerne également l'utilisation du nouveau polymorphe pour le traitement de maladies, telles que la dermatite atopique (AD), les démangeaisons, le prurit et diverses formes d'urticaire, par exemple des sous-types d'urticaire idiopathique chronique.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | A PROCESS FOR THE MANUFACTURE OF SALTS AND CRYSTALLINE FORMS OF 1-(8-BROMOPYRIDO[2,3-E][1,2,4]TRIAZOLO[4,3-A]PYRAZIN-4-YL)-N-METHYLAZETIDIN-3-AMINE AND NOVEL CRYSTALLINE FORMS |
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