A PROCESS FOR THE MANUFACTURE OF SALTS AND CRYSTALLINE FORMS OF 1-(8-BROMOPYRIDO[2,3-E][1,2,4]TRIAZOLO[4,3-A]PYRAZIN-4-YL)-N-METHYLAZETIDIN-3-AMINE AND NOVEL CRYSTALLINE FORMS

A PROCESS FOR THE MANUFACTURE OF SALTS AND CRYSTALLINE FORMS OF 1-(8-BROMOPYRIDO[2,3-E][1,2,4]TRIAZOLO[4,3-A]PYRAZIN-4-YL)-N-METHYLAZETIDIN-3-AMINE AND NOVEL CRYSTALLINE FORMS

A novel process for preparation of crystalline forms and novel crystalline forms of 1-(8- bromopyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-4-yl)-N-methylazetidin-3-amine salts is provided along with pharmaceutical compositions comprising the same. Also disclosed is the use of the novel polymorph for...

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Bibliographische Detailangaben
Hauptverfasser: TROENSEGAARD NIELSEN, Kim, HOFMANN LARSEN, Flemming, KLARSKOV PETERSEN, Anders
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:A novel process for preparation of crystalline forms and novel crystalline forms of 1-(8- bromopyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-4-yl)-N-methylazetidin-3-amine salts is provided along with pharmaceutical compositions comprising the same. Also disclosed is the use of the novel polymorph for the treatment of diseases, such as atopic dermatitis (AD), itch, pruritus and various forms of urticaria for example chronic idiopathic urticaria subtypes. L'invention concerne un nouveau procédé de préparation de formes cristallines et de nouvelles formes cristallines de sels de 1-(8-bromopyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-4-yl)-N-méthylazétidin-3-amine ainsi que des compositions pharmaceutiques les comprenant. L'invention concerne également l'utilisation du nouveau polymorphe pour le traitement de maladies, telles que la dermatite atopique (AD), les démangeaisons, le prurit et diverses formes d'urticaire, par exemple des sous-types d'urticaire idiopathique chronique.