S-KETAMINE TRANSDERMAL COMPOSITION AND PREPARATION METHOD THEREFOR AND USE THEREOF

Disclosed herein are an S-ketamine transdermal composition and a preparation method therefor and use thereof. The transdermal composition comprises S-ketamine or a pharmaceutically acceptable salt thereof, an acrylate pressure-sensitive adhesive without substitution of a functional group, and a fatt...

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Bibliographische Detailangaben
Hauptverfasser:	XIANG, Yongyao, LI, Ke, WU, Youbin, LIU, Can, LI, Min, LI, Lie, LV, Jinliang, LIU, Peng, WANG, Jinyu, CHEN, Yi
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed herein are an S-ketamine transdermal composition and a preparation method therefor and use thereof. The transdermal composition comprises S-ketamine or a pharmaceutically acceptable salt thereof, an acrylate pressure-sensitive adhesive without substitution of a functional group, and a fatty acid, wherein the mass ratio of the S-ketamine to the fatty acid is (1:2)-(1:1). When the transdermal composition of the present invention is administered, the cumulative flux per unit area of S-ketamine is increased, the drug delivery rate and degree are good, and sustained release of an active ingredient for 2 days or more or 3 days or more can be achieved. In addition, the transdermal composition of the present invention features good stability, good compatibility with skin, no irritation, good adhesion performance, convenience in use, and high patient use compliance, and can meet the requirements of industrial scale production. L'invention concerne une composition transdermique de S-kétamine et son procédé de