SYSTEMS AND METHODS FOR IDENTIFYING AND TARGETING COLLATERAL LETHAL GENES

Provided herein are systems and methods for identifying collateral lethal genes via metabolic fluxes and the use of such genes for the identification of, selections of, and use of therapeutic agents. Further provided herein are identified targets, such as MTHFD2, that may be regulated to treat or pr...

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Hauptverfasser:	WUCHU, Fulei, ANIMASAHUN, Olamide, ACHREJA, Abhinav, NAGRATH, Deepak, NENWANI, Minal
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided herein are systems and methods for identifying collateral lethal genes via metabolic fluxes and the use of such genes for the identification of, selections of, and use of therapeutic agents. Further provided herein are identified targets, such as MTHFD2, that may be regulated to treat or prevent diseases and conditions. L'invention concerne des systèmes et des procédés pour identifier des gènes létaux collatéraux par l'intermédiaire de flux métaboliques et l'utilisation de tels gènes pour l'identification, les sélections et l'utilisation d'agents thérapeutiques. L'invention concerne en outre des cibles identifiées, telles que MTHFD2, qui peuvent être régulées pour traiter ou prévenir des maladies et des états.