DRUGS TARGETING TELOMERASE REVERSE TRANSCRIPTASE (TERT) FOR TREATMENT OF CANCERS

TERT plays a crucial role in cancer formation, ensuring chromosomal stability by maintaining telomere length and allowing cells to avoid senescence. Development of telomerase inhibitors has been challenging and thus far there are no clinically approved strategies exploiting this cancer target. Discl...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	TAPINOS, Nikolaos, SUITA, Yusuke, PIZZAGALLI, Mattia
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	TERT plays a crucial role in cancer formation, ensuring chromosomal stability by maintaining telomere length and allowing cells to avoid senescence. Development of telomerase inhibitors has been challenging and thus far there are no clinically approved strategies exploiting this cancer target. Disclosed here is a method to treat cancer using compounds that perform combinatorial targeting of the telomerase and the RNA-dependent RNA polymerase activity of TERT. L'invention concerne une méthode de traitement du cancer au moyen de composés qui effectuent un ciblage combinatoire de la télomérase et de l'activité de l'ARN polymérase ARN-dépendante de TERT.