COMPOSITION FOR DENTIN ADHESION AND COMPOSITION FOR PULP RESTORATION, EACH COMPOSITION CONTAINING CPNE7-DERIVED PEPTIDE

A dentin adhesion composition according to the present invention contains a peptide composed of the amino acid sequence of the following general formula 1: K-Y-R1-R2-R3-R4-R5-R6-R7-R8 (General formula 1), in general formula 1, R1 is arginine (R), lysine (K), or glutamine (Q); R2 is arginine (R) or g...

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Bibliographische Detailangaben
Hauptverfasser: GUG, Hye Ri, SHON, Won Jun, PARK, Joo Hwang
Format: Patent
Sprache:eng ; fre ; kor
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Zusammenfassung:A dentin adhesion composition according to the present invention contains a peptide composed of the amino acid sequence of the following general formula 1: K-Y-R1-R2-R3-R4-R5-R6-R7-R8 (General formula 1), in general formula 1, R1 is arginine (R), lysine (K), or glutamine (Q); R2 is arginine (R) or glutamine (Q); R3, R4, and R5 are each arginine (R) or lysine (K); R6 is asparagine (N) or serine (S); and R7 and R8 are lysine (K) or tyrosine (Y). The composition according to the present invention is applied to the treatment of damaged dentin, such as dental caries or fractures, and thus can prevent possible dentin necrosis, dental extraction, or dental loss after treatment. Une composition d'adhésion dentinaire selon la présente invention contient un peptide composé de la séquence d'acides aminés de formule générale 1 suivante : K-Y-R1-R2-R3-R4-R5-R6-R7-R8 (formule générale 1). Dans la formule générale 1, R1 représente l'arginine (R), la lysine (K) ou la glutamine (Q) ; R2 représente l'arginine (R) ou la glutamine (Q) ; R3, R4 et R5 représentent respectivement l'arginine (R) ou la lysine (K) ; R6 représente l'asparagine (N) ou la sérine (S) ; et R7 et R8 représentent la lysine (K) ou la tyrosine (Y). La composition selon la présente invention est utilisée pour le traitement de la dentine endommagée, par exemple dans le cas de caries ou de fractures dentaires, et peut ainsi prévenir une éventuelle nécrose de la dentine, une extraction dentaire ou une perte dentaire après traitement. 본 발명에 따른 상아질 접착용 조성물은 하기 일반식 1의 아미노산 서열로 구성된 펩타이드를 포함한다: K-Y-R1-R2-R3-R4-R5-R6-R7-R8 (일반식 1), 상기 일반식 1에서, R1은 아르기닌(R), 리신(K) 또는 글루타민(Q)이고; R2는 아르기닌(R) 또는 글루타민(Q)이며; R3, R4 및 R5는 각각 아르기닌(R) 또는 리신(K)이고; R6는 아스파라긴(N) 또는 세린(S)이며; 및 R7 및 R8은 리신(K) 또는 타이로신(Y)이다. 본 발명에 따른 조성물은 치아우식증, 파절 등 손상된 치질의 치료에 사용되어 치료 이후 발생가능한 치수의 괴사, 치아 삭제 또는 치아 손실을 방지할 수 있다.