PROCESSES FOR GENERATING TIL PRODUCTS USING PD-1/TIGIT TALEN DOUBLE KNOCKDOWN
The present invention provides methods for preparing expanded tumor infiltrating lymphocytes (TILs) having reduced expression of PD-1 and TIGIT using sequential electroporation of two TALEN systems targeting PD-1 and TIGIT. Such TILs find use in therapeutic treatment regimens for cancer patients. La...
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| creator | VEERAPATHRAN, Anand GONTCHAROVA, Viktoria JUILLERAT, Alexandre QI, Rongsu MACHIN, Marcus VOGT, Frederick POIROT, Laurent CUBAS, Rafael YIN, Hequn BUNCH, Brittany BOYNE, Alex |
| description | The present invention provides methods for preparing expanded tumor infiltrating lymphocytes (TILs) having reduced expression of PD-1 and TIGIT using sequential electroporation of two TALEN systems targeting PD-1 and TIGIT. Such TILs find use in therapeutic treatment regimens for cancer patients.
La présente invention concerne des procédés de préparation de lymphocytes infiltrant les tumeurs (TIL) expansés ayant une expression réduite de PD-1 et TIGIT à l'aide d'une électroporation séquentielle de deux systèmes TALEN ciblant PD-1 et TIGIT. De tels TIL trouvent une utilisation dans des régimes de traitement thérapeutique pour des patients atteints d'un cancer. |
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La présente invention concerne des procédés de préparation de lymphocytes infiltrant les tumeurs (TIL) expansés ayant une expression réduite de PD-1 et TIGIT à l'aide d'une électroporation séquentielle de deux systèmes TALEN ciblant PD-1 et TIGIT. De tels TIL trouvent une utilisation dans des régimes de traitement thérapeutique pour des patients atteints d'un cancer.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240314&DB=EPODOC&CC=WO&NR=2024055018A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240314&DB=EPODOC&CC=WO&NR=2024055018A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>VEERAPATHRAN, Anand</creatorcontrib><creatorcontrib>GONTCHAROVA, Viktoria</creatorcontrib><creatorcontrib>JUILLERAT, Alexandre</creatorcontrib><creatorcontrib>QI, Rongsu</creatorcontrib><creatorcontrib>MACHIN, Marcus</creatorcontrib><creatorcontrib>VOGT, Frederick</creatorcontrib><creatorcontrib>POIROT, Laurent</creatorcontrib><creatorcontrib>CUBAS, Rafael</creatorcontrib><creatorcontrib>YIN, Hequn</creatorcontrib><creatorcontrib>BUNCH, Brittany</creatorcontrib><creatorcontrib>BOYNE, Alex</creatorcontrib><title>PROCESSES FOR GENERATING TIL PRODUCTS USING PD-1/TIGIT TALEN DOUBLE KNOCKDOWN</title><description>The present invention provides methods for preparing expanded tumor infiltrating lymphocytes (TILs) having reduced expression of PD-1 and TIGIT using sequential electroporation of two TALEN systems targeting PD-1 and TIGIT. Such TILs find use in therapeutic treatment regimens for cancer patients.
La présente invention concerne des procédés de préparation de lymphocytes infiltrant les tumeurs (TIL) expansés ayant une expression réduite de PD-1 et TIGIT à l'aide d'une électroporation séquentielle de deux systèmes TALEN ciblant PD-1 et TIGIT. De tels TIL trouvent une utilisation dans des régimes de traitement thérapeutique pour des patients atteints d'un cancer.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPANCPJ3dg0Odg1WcPMPUnB39XMNcgzx9HNXCPH0UQBKuoQ6hwQrhAaDhAJcdA31QzzdPUMUQhx9XP0UXPxDnXxcFbz9_J29XfzD_XgYWNMSc4pTeaE0N4Oym2uIs4duakF-fGpxQWJyal5qSXy4v5GBkYmBqamBoYWjoTFxqgCl_C8e</recordid><startdate>20240314</startdate><enddate>20240314</enddate><creator>VEERAPATHRAN, Anand</creator><creator>GONTCHAROVA, Viktoria</creator><creator>JUILLERAT, Alexandre</creator><creator>QI, Rongsu</creator><creator>MACHIN, Marcus</creator><creator>VOGT, Frederick</creator><creator>POIROT, Laurent</creator><creator>CUBAS, Rafael</creator><creator>YIN, Hequn</creator><creator>BUNCH, Brittany</creator><creator>BOYNE, Alex</creator><scope>EVB</scope></search><sort><creationdate>20240314</creationdate><title>PROCESSES FOR GENERATING TIL PRODUCTS USING PD-1/TIGIT TALEN DOUBLE KNOCKDOWN</title><author>VEERAPATHRAN, Anand ; GONTCHAROVA, Viktoria ; JUILLERAT, Alexandre ; QI, Rongsu ; MACHIN, Marcus ; VOGT, Frederick ; POIROT, Laurent ; CUBAS, Rafael ; YIN, Hequn ; BUNCH, Brittany ; BOYNE, Alex</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024055018A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>VEERAPATHRAN, Anand</creatorcontrib><creatorcontrib>GONTCHAROVA, Viktoria</creatorcontrib><creatorcontrib>JUILLERAT, Alexandre</creatorcontrib><creatorcontrib>QI, Rongsu</creatorcontrib><creatorcontrib>MACHIN, Marcus</creatorcontrib><creatorcontrib>VOGT, Frederick</creatorcontrib><creatorcontrib>POIROT, Laurent</creatorcontrib><creatorcontrib>CUBAS, Rafael</creatorcontrib><creatorcontrib>YIN, Hequn</creatorcontrib><creatorcontrib>BUNCH, Brittany</creatorcontrib><creatorcontrib>BOYNE, Alex</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>VEERAPATHRAN, Anand</au><au>GONTCHAROVA, Viktoria</au><au>JUILLERAT, Alexandre</au><au>QI, Rongsu</au><au>MACHIN, Marcus</au><au>VOGT, Frederick</au><au>POIROT, Laurent</au><au>CUBAS, Rafael</au><au>YIN, Hequn</au><au>BUNCH, Brittany</au><au>BOYNE, Alex</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESSES FOR GENERATING TIL PRODUCTS USING PD-1/TIGIT TALEN DOUBLE KNOCKDOWN</title><date>2024-03-14</date><risdate>2024</risdate><abstract>The present invention provides methods for preparing expanded tumor infiltrating lymphocytes (TILs) having reduced expression of PD-1 and TIGIT using sequential electroporation of two TALEN systems targeting PD-1 and TIGIT. Such TILs find use in therapeutic treatment regimens for cancer patients.
La présente invention concerne des procédés de préparation de lymphocytes infiltrant les tumeurs (TIL) expansés ayant une expression réduite de PD-1 et TIGIT à l'aide d'une électroporation séquentielle de deux systèmes TALEN ciblant PD-1 et TIGIT. De tels TIL trouvent une utilisation dans des régimes de traitement thérapeutique pour des patients atteints d'un cancer.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | PROCESSES FOR GENERATING TIL PRODUCTS USING PD-1/TIGIT TALEN DOUBLE KNOCKDOWN |
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