PROCESSES FOR GENERATING TIL PRODUCTS USING PD-1/TIGIT TALEN DOUBLE KNOCKDOWN

The present invention provides methods for preparing expanded tumor infiltrating lymphocytes (TILs) having reduced expression of PD-1 and TIGIT using sequential electroporation of two TALEN systems targeting PD-1 and TIGIT. Such TILs find use in therapeutic treatment regimens for cancer patients. La...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	VEERAPATHRAN, Anand, GONTCHAROVA, Viktoria, JUILLERAT, Alexandre, QI, Rongsu, MACHIN, Marcus, VOGT, Frederick, POIROT, Laurent, CUBAS, Rafael, YIN, Hequn, BUNCH, Brittany, BOYNE, Alex
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention provides methods for preparing expanded tumor infiltrating lymphocytes (TILs) having reduced expression of PD-1 and TIGIT using sequential electroporation of two TALEN systems targeting PD-1 and TIGIT. Such TILs find use in therapeutic treatment regimens for cancer patients. La présente invention concerne des procédés de préparation de lymphocytes infiltrant les tumeurs (TIL) expansés ayant une expression réduite de PD-1 et TIGIT à l'aide d'une électroporation séquentielle de deux systèmes TALEN ciblant PD-1 et TIGIT. De tels TIL trouvent une utilisation dans des régimes de traitement thérapeutique pour des patients atteints d'un cancer.