PANNEXIN-1 MODULATORS AND METHODS OF TREATING DISORDERS IN WHICH PANNEXIN-1 IS IMPLICATED

Disclosed herein are small molecule modulators of pannexin. Also disclosed herein are methods of treating disorders associated with exacerbated activation of ATP- induced signal pathways mediated by pannexin, such as pain and opioid addiction, by administering small molecule modulators of pannexin....

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Bibliographische Detailangaben
Hauptverfasser:	LÓPEZ, David Alexandre, GROSS, Gerhard Max
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Disclosed herein are small molecule modulators of pannexin. Also disclosed herein are methods of treating disorders associated with exacerbated activation of ATP- induced signal pathways mediated by pannexin, such as pain and opioid addiction, by administering small molecule modulators of pannexin. L'invention concerne des modulateurs à petites molécules de la pannexine. L'invention concerne également des méthodes de traitement de troubles associés à l'activation exacerbée de voies de signal induites par l'ATP médiées par la pannexine, telles que la douleur et la dépendance aux opioïdes, par l'administration de modulateurs à petites molécules de la pannexine.