PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS

This disclosure provides peptide based compounds, compositions, and methods to treat medical disordeds, such as complement-mediated disorders, including complement C1s-mediated disorders, such as acute antibody-mediated rejection, amyotrophic lateral sclerosis, autoimmune blistering disease, bullous...

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Hauptverfasser: GADHACHANDA, Venkat Rao, ZHOU, Qi, ONYANGO, Evans O
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:This disclosure provides peptide based compounds, compositions, and methods to treat medical disordeds, such as complement-mediated disorders, including complement C1s-mediated disorders, such as acute antibody-mediated rejection, amyotrophic lateral sclerosis, autoimmune blistering disease, bullous pemphigoid, geographic atrophy, or Guillain-Barre Syndrome, comprising administering to a subject in need thereof a therapeutically effective amount of the compound. La présente divulgation concerne des composés, des compositions et des méthodes destinés au traitement de troubles médicaux, tels que des troubles médiés par le complément, y compris des troubles médiés par le complément C1s.