RECOMBINANT AAVS WITH IMPROVED TROPISM AND SPECIFICITY

The present disclosure provides a modified AAV capsid protein comprising a targeting peptide in variable region VIII (VR. VIII) and/or a peptide segment in variable region I (VR I). The modified AAV capsid protein can form an rAAV, which has a preferred tropism, specificity or biodistribution in viv...

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Hauptverfasser:	ALBRIGHT, Charles Francis, CAO, Xiaohong, TAN, Jie, OLIVIERI, Kevin C
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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