LIPID-PEGYLATED COMPOUNDS, PREPARATIONS AND USES THEREOF

Embodiments of the present disclosure relate to lipid-PEGylated solid support and phosphoramidites derivatives, methods for preparing the same, and their uses in the delivery of oligonucleotide drugs to the cellular targets. Des modes de réalisation de la présente divulgation concernent des supports...

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Bibliographische Detailangaben
Hauptverfasser:	ZOU, Ruiming, ZHAO, Gang, WONG, Allen, YU, David, YAO, Yun-Chiao, DU, Gengyu, LAU, Aldrich N.K, LI, Xiaojun, POON, Wing C, ZOU, Mufa
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY COMBINATORIAL CHEMISTRY DERIVATIVES THEREOF LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SUGARS
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Beschreibung
Zusammenfassung:	Embodiments of the present disclosure relate to lipid-PEGylated solid support and phosphoramidites derivatives, methods for preparing the same, and their uses in the delivery of oligonucleotide drugs to the cellular targets. Des modes de réalisation de la présente divulgation concernent des supports solides pégylés lipidiques et des dérivés de phosphoramidites, leurs procédés de préparation, et leurs utilisations dans l'administration de médicaments oligonucléotidiques à des cibles cellulaires.